OBJECTIVES/HYPOTHESIS: In the present study we sought to define the outcome of patients with delay in diagnosis and treatment (>1 year) of well-differentiated thyroid carcinoma (WDTC) due to initial benign cytology (IBC). STUDY DESIGN: Retrospective medical record review and analysis of survival outcomes. METHODS: The records of 47 patients with delayed diagnosis of thyroid cancer were reviewed. In 38, surgery was performed for growing nodules and in nine due to malignant cytology during follow-up. Median time to delayed surgery was 52 months (range, 13-205 months). Multivariate analysis was performed to assess variables associated with outcome. RESULTS: Most patients (32/47) underwent total thyroidectomy, whereas 15/47 had hemithyroidectomy. With a median follow-up of 96 months (range, 12-184 months), the 5-year disease-free survival of these patients was 96%. Multivariate analysis showed that the outcome of these patients was not statistically different than that of patients (n = 162) who underwent immediate surgery for similar disease. CONCLUSIONS: We show that patients with delayed diagnosis and treatment for WDTC due to IBC have excellent outcome. LEVEL OF EVIDENCE: 4.
OBJECTIVES/HYPOTHESIS: In the present study we sought to define the outcome of patients with delay in diagnosis and treatment (>1 year) of well-differentiated thyroid carcinoma (WDTC) due to initial benign cytology (IBC). STUDY DESIGN: Retrospective medical record review and analysis of survival outcomes. METHODS: The records of 47 patients with delayed diagnosis of thyroid cancer were reviewed. In 38, surgery was performed for growing nodules and in nine due to malignant cytology during follow-up. Median time to delayed surgery was 52 months (range, 13-205 months). Multivariate analysis was performed to assess variables associated with outcome. RESULTS: Most patients (32/47) underwent total thyroidectomy, whereas 15/47 had hemithyroidectomy. With a median follow-up of 96 months (range, 12-184 months), the 5-year disease-free survival of these patients was 96%. Multivariate analysis showed that the outcome of these patients was not statistically different than that of patients (n = 162) who underwent immediate surgery for similar disease. CONCLUSIONS: We show that patients with delayed diagnosis and treatment for WDTC due to IBC have excellent outcome. LEVEL OF EVIDENCE: 4.
Authors: Reagan A Collins; Catherine DiGennaro; Toni Beninato; Rajshri M Gartland; Natalia Chaves; Jordan M Broekhuis; Lekha Reddy; Jenna Lee; Angelina Deimiller; Maeve M Alterio; Michael J Campbell; Yeon Joo Lee; Tyler K Khilnani; Latoya A Stewart; Mollie A O'Brien; Miguel Valdivia Y Alvarado; Feibi Zheng; David McAneny; Rachel Liou; Catherine McManus; Sophie Y Dream; Tracy S Wang; Tina W Yen; Amal Alhefdhi; Brendan M Finnerty; Thomas J Fahey; Claire E Graves; Amanda M Laird; Matthew A Nehs; Frederick Thurston Drake; James A Lee; Christopher R McHenry; Benjamin C James; Janice L Pasieka; Jennifer H Kuo; Carrie Cunningham Lubitz Journal: Surgery Date: 2022-08-29 Impact factor: 4.348
Authors: Michael C Topf; Jared A Shenson; F Christopher Holsinger; Samuel H Wald; Lisa J Cianfichi; Eben L Rosenthal; John B Sunwoo Journal: Head Neck Date: 2020-05-06 Impact factor: 3.147
Authors: Denise Garcia; Julie B Siegel; David A Mahvi; Biqi Zhang; David M Mahvi; E Ramsay Camp; Whitney Graybill; Stephen J Savage; Antonio Giordano; Sara Giordano; Denise Carneiro-Pla; Mahsa Javid; Aaron P Lesher; Andrea Abbott; Nancy Klauber DeMore Journal: Clin Oncol Res Date: 2020-06-26