| Literature DB >> 24867167 |
Masoumeh Heidary1, Nahid Rakhshi2, Majid Pahlevan Kakhki3, Mehrdad Behmanesh4, Mohammad Hossein Sanati5, Nima Sanadgol6, Hossein Kamaladini7, Abbas Nikravesh8.
Abstract
IL-1B is released by monocytes, astrocytes and brain endothelial cells and seems to be involved in inflammatory reactions of the central nervous system (CNS) in multiple sclerosis (MS). This study aims to evaluate the expression level of IL-1B mRNA in peripheral blood mononuclear cells (PBMCs), genotype the rs16944 SNP and find out the role of this SNP on the expression level of IL-1B in MS patients. We found that the expression level of IL-1B in MS patients increased 3.336 times more than controls in PBMCs but the rs16944 SNP in the promoter region of IL-1B did not affect the expression level of this gene and there was not association of this SNP with MS in the examined population. Also, our data did not reveal any correlation between normalized expressions of IL-1B gene with age of participants, age of onset, and disease duration.Entities:
Keywords: Cytokines; Gene expression; Genotyping; IL-1B; Inflammation; Multiple sclerosis
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Year: 2014 PMID： 24867167 DOI： 10.1016/j.jns.2014.05.013
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181