Shashi Prabha1, Geeta Arya2, Ramesh Chandra3, Bahar Ahmed1, Surendra Nimesh2. 1. a Department of Pharmaceutical Chemistry , Jamia Hamdard University , New Delhi , India. 2. b Department of Biotechnology , School of Life Sciences, Central University of Rajasthan , Ajmer , Rajasthan , India. 3. c Department of Chemistry , University of Delhi , Delhi , India.
Abstract
CONTEXT: The size of nanoparticles plays a pivotal role in determining the gene delivery efficiency. OBJECTIVE: A focus on the studies done to investigate the effect of nanoparticles size on biological aspects of gene delivery. METHODS: A through literature survey has been done regarding studies done to investigate the effect of nanoparticles size on uptake, transfection efficiency and biodistribution has been cited in the present review. RESULTS AND CONCLUSION: The gene delivery efficacy may depend on conjugation of several factors such as the chemical structure of polymers, cell type, and nanoparticle size, composition and interaction with cells.
CONTEXT: The size of nanoparticles plays a pivotal role in determining the gene delivery efficiency. OBJECTIVE: A focus on the studies done to investigate the effect of nanoparticles size on biological aspects of gene delivery. METHODS: A through literature survey has been done regarding studies done to investigate the effect of nanoparticles size on uptake, transfection efficiency and biodistribution has been cited in the present review. RESULTS AND CONCLUSION: The gene delivery efficacy may depend on conjugation of several factors such as the chemical structure of polymers, cell type, and nanoparticle size, composition and interaction with cells.
Authors: Surasa Nagachinta; Belen Lopez Bouzo; Abi Judit Vazquez-Rios; Rafael Lopez; Maria de la Fuente Journal: Pharmaceutics Date: 2020-02-22 Impact factor: 6.321