Literature DB >> 24866462

Antenatal taurine improves neuronal regeneration in fetal rats with intrauterine growth restriction by inhibiting the Rho-ROCK signal pathway.

Jing Liu1, Hua-Wei Wang, Fang Liu, Xiao-Feng Wang.   

Abstract

The Rho-ROCK signal pathway is an important mediator of inhibitory signals that blocks central nervous cell regeneration. Here, we investigated whether antenatal taurine improved neuronal regeneration in fetal rats with intrauterine growth restriction (IUGR) by inhibiting this pathway. Thirty pregnant rats were randomly divided into three groups: control, IUGR, and IUGR + antenatal taurine supplementation (taurine group). The mRNA levels of Ras homolog gene A (Rho A), Rho-associated coiled-coil forming protein kinase 2 (ROCK2), and proliferating cell nuclear antigen (PCNA) were detected using real-time quantitative PCR. RhoA, ROCK2 and PCNA-positive cells were counted using immunohistochemistry. Antenatal taurine supplementation decreased RhoA and Rock2 mRNA expression, increased PCNA mRNA expression, and significantly decreased RhoA, ROCK2-positive and increased PCNA-positive cell counts in IUGR fetal rat brain tissues (p < 0.05). Thus, antenatal taurine supplementation inhibited the expression of key Rho-ROCK signal molecules and improved IUGR fetal brain development.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24866462     DOI： 10.1007/s11011-014-9572-x

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  30 in total

1.  Antenatal taurine supplementation improves cerebral neurogenesis in fetal rats with intrauterine growth restriction through the PKA-CREB signal pathway.

Authors:  Jing Liu; Ying Liu; Xiao-Feng Wang; Hui Chen; Na Yang
Journal:  Nutr Neurosci       Date:  2013-02-19       Impact factor: 4.994

2.  Intrauterine low protein diet increases fetal beta-cell sensitivity to NO and IL-1 beta: the protective role of taurine.

Authors:  S Merezak; A A Hardikar; C S Yajnik; C Remacle; B Reusens
Journal:  J Endocrinol       Date:  2001-11       Impact factor: 4.286

3.  Effect of taurine on brain 8-hydroxydeoxyguanosine and 3-nitrotyrosine levels in endotoxemia.

Authors:  Gonca Ozan; Nurten Turkozkan; Filiz Sezen Bircan; Barbaros Balabanli
Journal:  Inflammation       Date:  2012-04       Impact factor: 4.092

4.  Antenatal supplementation of taurine for protection of fetal rat brain with intrauterine growth restriction from injury by reducing neuronal apoptosis.

Authors:  Jing Liu; Li Liu; Xiao-Feng Wang; Hui-Yun Teng; Na Yang
Journal:  Neuropediatrics       Date:  2012-08-29       Impact factor: 1.947

5.  Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.

Authors:  Jing Ding; Qin-Ying Li; Xin Wang; Chang-Hai Sun; Chuan-Zhen Lu; Bao-Guo Xiao
Journal:  J Neurochem       Date:  2010-09       Impact factor: 5.372

6.  Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-year prospective study.

Authors:  Yael Leitner; Aviva Fattal-Valevski; Ronny Geva; Rina Eshel; Hagit Toledano-Alhadef; Michael Rotstein; Haim Bassan; Bella Radianu; Ora Bitchonsky; Ariel J Jaffa; Shaul Harel
Journal:  J Child Neurol       Date:  2007-05       Impact factor: 1.987

7.  Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.

Authors:  Shin-ichi Satoh; Yoshinori Toshima; Asako Hitomi; Ichiro Ikegaki; Minoru Seto; Toshio Asano
Journal:  Brain Res       Date:  2007-12-04       Impact factor: 3.252

8.  Patterns of Nogo-A, NgR, and RhoA expression in the brain tissues of rats with focal cerebral infarction.

Authors:  Wen Jiang; Feng Xia; Junliang Han; Jincun Wang
Journal:  Transl Res       Date:  2009-05-19       Impact factor: 7.012

9.  Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.

Authors:  Paul Lingor; Nicole Teusch; Katrin Schwarz; Reinhold Mueller; Helmut Mack; Mathias Bähr; Bernhard K Mueller
Journal:  J Neurochem       Date:  2007-07-02       Impact factor: 5.372

Review 10.  Review: taurine: a "very essential" amino acid.

Authors:  Harris Ripps; Wen Shen
Journal:  Mol Vis       Date:  2012-11-12       Impact factor: 2.367
View more
  5 in total

Review 1.  Therapeutic potential to reduce brain injury in growth restricted newborns.

Authors:  Julie A Wixey; Kirat K Chand; Lily Pham; Paul B Colditz; S Tracey Bjorkman
Journal:  J Physiol       Date:  2018-05-23       Impact factor: 5.182

2.  Taurine improves the differentiation of neural stem cells in fetal rats with intrauterine growth restriction via activation of the PKA-CREB-BDNF signaling pathway.

Authors:  Qiong Fang; Jing Liu; Lang Chen; Qiaobin Chen; Jun Ke; Jiuyun Zhang; Ying Liu; Wei Fu
Journal:  Metab Brain Dis       Date:  2021-02-20       Impact factor: 3.584

3.  Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine.

Authors:  Hanaa A Khalaf; Ayman Z Elsamanoudy; Salwa M Abo-Elkhair; Fatma E Hassan; Passant M Mohie; Fatma M Ghoneim
Journal:  Histochem Cell Biol       Date:  2022-05-05       Impact factor: 2.531

4.  Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis.

Authors:  Qiong Fang; Jing Liu; Lang Chen; Qiaobin Chen; Yan Wang; Zuanfang Li; Wei Fu; Ying Liu
Journal:  Metab Brain Dis       Date:  2022-01-20       Impact factor: 3.655

5.  Taurine ameliorates volatile organic compounds-induced cognitive impairment in young rats via suppressing oxidative stress, regulating neurotransmitter and activating NMDA receptor.

Authors:  Yongchao Gao; Chao Sun; Ting Gao; Zhiyong Liu; Zhao Yang; Hui Deng; Peng Fan; Junhong Gao
Journal:  Front Vet Sci       Date:  2022-09-16
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.