Literature DB >> 24866187

PARK2 orchestrates cyclins to avoid cancer.

Jiri Bartek1, Zdenek Hodny2.   

Abstract

Proper control of cyclin-dependent kinases ensures coordinated cell cycle progression and guards against tumorigenesis. A new study identifies the PARK2 E3 ubiquitin ligase as an important coordinator of G1/S-phase cyclin turnover and explains how mutations targeting this key cell cycle regulatory node contribute to a range of cancers.

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Year:  2014        PMID： 24866187     DOI： 10.1038/ng.2992

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

Review 1.  The retinoblastoma protein pathway and the restriction point.

Authors:  J Bartek; J Bartkova; J Lukas
Journal:  Curr Opin Cell Biol       Date:  1996-12       Impact factor: 8.382

Review 2.  Targeting cyclin-dependent kinases in anti-neoplastic therapy.

Authors:  Céline Bruyère; Laurent Meijer
Journal:  Curr Opin Cell Biol       Date:  2013-09-06       Impact factor: 8.382

3.  DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.

Authors:  Jirina Bartkova; Zuzana Horejsí; Karen Koed; Alwin Krämer; Frederic Tort; Karsten Zieger; Per Guldberg; Maxwell Sehested; Jahn M Nesland; Claudia Lukas; Torben Ørntoft; Jiri Lukas; Jiri Bartek
Journal:  Nature       Date:  2005-04-14       Impact factor: 49.962

4.  Mutual exclusivity analysis identifies oncogenic network modules.

Authors:  Giovanni Ciriello; Ethan Cerami; Chris Sander; Nikolaus Schultz
Journal:  Genome Res       Date:  2011-09-09       Impact factor: 9.043

5.  Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.

Authors:  Selvaraju Veeriah; Barry S Taylor; Shasha Meng; Fang Fang; Emrullah Yilmaz; Igor Vivanco; Manickam Janakiraman; Nikolaus Schultz; Aphrothiti J Hanrahan; William Pao; Marc Ladanyi; Chris Sander; Adriana Heguy; Eric C Holland; Philip B Paty; Paul S Mischel; Linda Liau; Timothy F Cloughesy; Ingo K Mellinghoff; David B Solit; Timothy A Chan
Journal:  Nat Genet       Date:  2009-11-29       Impact factor: 38.330

Review 6.  An oncogene-induced DNA damage model for cancer development.

Authors:  Thanos D Halazonetis; Vassilis G Gorgoulis; Jiri Bartek
Journal:  Science       Date:  2008-03-07       Impact factor: 47.728

Review 7.  Mechanisms and function of substrate recruitment by F-box proteins.

Authors:  Jeffrey R Skaar; Julia K Pagan; Michele Pagano
Journal:  Nat Rev Mol Cell Biol       Date:  2013-05-09       Impact factor: 94.444

8.  The landscape of somatic copy-number alteration across human cancers.

Authors:  Rameen Beroukhim; Craig H Mermel; Dale Porter; Guo Wei; Soumya Raychaudhuri; Jerry Donovan; Jordi Barretina; Jesse S Boehm; Jennifer Dobson; Mitsuyoshi Urashima; Kevin T Mc Henry; Reid M Pinchback; Azra H Ligon; Yoon-Jae Cho; Leila Haery; Heidi Greulich; Michael Reich; Wendy Winckler; Michael S Lawrence; Barbara A Weir; Kumiko E Tanaka; Derek Y Chiang; Adam J Bass; Alice Loo; Carter Hoffman; John Prensner; Ted Liefeld; Qing Gao; Derek Yecies; Sabina Signoretti; Elizabeth Maher; Frederic J Kaye; Hidefumi Sasaki; Joel E Tepper; Jonathan A Fletcher; Josep Tabernero; José Baselga; Ming-Sound Tsao; Francesca Demichelis; Mark A Rubin; Pasi A Janne; Mark J Daly; Carmelo Nucera; Ross L Levine; Benjamin L Ebert; Stacey Gabriel; Anil K Rustgi; Cristina R Antonescu; Marc Ladanyi; Anthony Letai; Levi A Garraway; Massimo Loda; David G Beer; Lawrence D True; Aikou Okamoto; Scott L Pomeroy; Samuel Singer; Todd R Golub; Eric S Lander; Gad Getz; William R Sellers; Matthew Meyerson
Journal:  Nature       Date:  2010-02-18       Impact factor: 49.962

9.  Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.

Authors:  Shireen A Sarraf; Malavika Raman; Virginia Guarani-Pereira; Mathew E Sowa; Edward L Huttlin; Steven P Gygi; J Wade Harper
Journal:  Nature       Date:  2013-03-17       Impact factor: 49.962

10.  CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination.

Authors:  Jacob Falck; Josep V Forment; Julia Coates; Martin Mistrik; Jiri Lukas; Jiri Bartek; Stephen P Jackson
Journal:  EMBO Rep       Date:  2012-06       Impact factor: 8.807
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  11 in total

1.  A recurrent mutation in PARK2 is associated with familial lung cancer.

Authors:  Donghai Xiong; Yian Wang; Elena Kupert; Claire Simpson; Susan M Pinney; Colette R Gaba; Diptasri Mandal; Ann G Schwartz; Ping Yang; Mariza de Andrade; Claudio Pikielny; Jinyoung Byun; Yafang Li; Dwight Stambolian; Margaret R Spitz; Yanhong Liu; Christopher I Amos; Joan E Bailey-Wilson; Marshall Anderson; Ming You
Journal:  Am J Hum Genet       Date:  2015-01-29       Impact factor: 11.025

2.  MAJOR MOLECULAR GENETIC DRIVERS IN SPORADIC PRIMARY HYPERPARATHYROIDISM.

Authors:  Andrew Arnold
Journal:  Trans Am Clin Climatol Assoc       Date:  2016

3.  Whole exome sequencing in familial isolated primary hyperparathyroidism.

Authors:  F Cetani; E Pardi; P Aretini; F Saponaro; S Borsari; L Mazoni; M Apicella; P Civita; M La Ferla; M A Caligo; F Lessi; C M Mazzanti; L Torregossa; A Oppo; C Marcocci
Journal:  J Endocrinol Invest       Date:  2019-09-05       Impact factor: 4.256

Review 4.  Pathologic and therapeutic implications for the cell biology of parkin.

Authors:  Rakshita A Charan; Matthew J LaVoie
Journal:  Mol Cell Neurosci       Date:  2015-02-17       Impact factor: 4.314

Review 5.  WWOX, large common fragile site genes, and cancer.

Authors:  Ge Gao; David I Smith
Journal:  Exp Biol Med (Maywood)       Date:  2015-01-16

6.  Association of a PARK2 Germline Variant and Epithelial Ovarian Cancer in a Southern Brazilian Population.

Authors:  Phamela Ferreira Klimczak; Danielle Hornung Ventury; Fabio Rueda Faucz; Nikolaos Settas; Cleber Machado de Souza; Vanessa Santos Sotomaior
Journal:  Oncology       Date:  2016-06-10       Impact factor: 2.935

Review 7.  Parkin in Parkinson's Disease and Cancer: a Double-Edged Sword.

Authors:  Khushnuma Wahabi; Ahmad Perwez; Moshahid A Rizvi
Journal:  Mol Neurobiol       Date:  2018-01-18       Impact factor: 5.590

8.  PARK2 inhibits osteosarcoma cell growth through the JAK2/STAT3/VEGF signaling pathway.

Authors:  Zhong Lei; Huijie Duan; Tengfei Zhao; Yuxiang Zhang; Guoqi Li; Jiahong Meng; Suzhan Zhang; Weiqi Yan
Journal:  Cell Death Dis       Date:  2018-03-07       Impact factor: 8.469

Review 9.  Parkin, an E3 Ubiquitin Ligase, Plays an Essential Role in Mitochondrial Quality Control in Parkinson's Disease.

Authors:  Xiao-Le Wang; Si-Tong Feng; Zhen-Zhen Wang; Yu-He Yuan; Nai-Hong Chen; Yi Zhang
Journal:  Cell Mol Neurobiol       Date:  2020-07-04       Impact factor: 5.046

10.  Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium.

Authors:  Sharon E Johnatty; Jonathan P Tyrer; Siddhartha Kar; Jonathan Beesley; Yi Lu; Bo Gao; Peter A Fasching; Alexander Hein; Arif B Ekici; Matthias W Beckmann; Diether Lambrechts; Els Van Nieuwenhuysen; Ignace Vergote; Sandrina Lambrechts; Mary Anne Rossing; Jennifer A Doherty; Jenny Chang-Claude; Francesmary Modugno; Roberta B Ness; Kirsten B Moysich; Douglas A Levine; Lambertus A Kiemeney; Leon F A G Massuger; Jacek Gronwald; Jan Lubiński; Anna Jakubowska; Cezary Cybulski; Louise Brinton; Jolanta Lissowska; Nicolas Wentzensen; Honglin Song; Valerie Rhenius; Ian Campbell; Diana Eccles; Weiva Sieh; Alice S Whittemore; Valerie McGuire; Joseph H Rothstein; Rebecca Sutphen; Hoda Anton-Culver; Argyrios Ziogas; Simon A Gayther; Aleksandra Gentry-Maharaj; Usha Menon; Susan J Ramus; Celeste L Pearce; Malcolm C Pike; Daniel O Stram; Anna H Wu; Jolanta Kupryjanczyk; Agnieszka Dansonka-Mieszkowska; Iwona K Rzepecka; Beata Spiewankiewicz; Marc T Goodman; Lynne R Wilkens; Michael E Carney; Pamela J Thompson; Florian Heitz; Andreas du Bois; Ira Schwaab; Philipp Harter; Jacobus Pisterer; Peter Hillemanns; Beth Y Karlan; Christine Walsh; Jenny Lester; Sandra Orsulic; Stacey J Winham; Madalene Earp; Melissa C Larson; Zachary C Fogarty; Estrid Høgdall; Allan Jensen; Susanne Kruger Kjaer; Brooke L Fridley; Julie M Cunningham; Robert A Vierkant; Joellen M Schildkraut; Edwin S Iversen; Kathryn L Terry; Daniel W Cramer; Elisa V Bandera; Irene Orlow; Tanja Pejovic; Yukie Bean; Claus Høgdall; Lene Lundvall; Ian McNeish; James Paul; Karen Carty; Nadeem Siddiqui; Rosalind Glasspool; Thomas Sellers; Catherine Kennedy; Yoke-Eng Chiew; Andrew Berchuck; Stuart MacGregor; Paul D P Pharoah; Ellen L Goode; Anna deFazio; Penelope M Webb; Georgia Chenevix-Trench
Journal:  Clin Cancer Res       Date:  2015-07-07       Impact factor: 12.531
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