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Literature DB >> 24865516

Targeting the unfolded protein response in heart diseases.

Abstract

In neurological disease and diabetes, the unfolded protein response (UPR) has been investigated for years, while its function in heart disease is less well understood. All three branches of the UPR are involved in ischaemia/reperfusion and can either protect or impair heart function. Recently, UPR has been found to play a role in arrhythmogenesis during human heart failure, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease.

Entities: Chemical Disease Gene Species

Keywords: activating transcription factor 6α; glucose-regulated protein-78; heart failure; inositol-requiring ER-to-nucleus signal kinase 1; ischaemia; protein kinase-like ER kinase

Mesh：

Year: 2014 PMID： 24865516 PMCID： PMC4878849 DOI： 10.1517/14728222.2014.918605

Source DB: PubMed Journal: Expert Opin Ther Targets ISSN： 1472-8222 Impact factor: 6.902

15 in total

1. Plasma cell differentiation requires the transcription factor XBP-1.

Authors: A M Reimold; N N Iwakoshi; J Manis; P Vallabhajosyula; E Szomolanyi-Tsuda; E M Gravallese; D Friend; M J Grusby; F Alt; L H Glimcher
Journal: Nature Date: 2001-07-19 Impact factor: 49.962

2. Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia.

Authors: Maurizio Vitadello; Daniele Penzo; Valeria Petronilli; Genny Michieli; Selena Gomirato; Roberta Menabò; Fabio Di Lisa; Luisa Gorza
Journal: FASEB J Date: 2003-03-28 Impact factor: 5.191

3. TRB3 function in cardiac endoplasmic reticulum stress.

Authors: Joan Avery; Sharon Etzion; Brian J DeBosch; Xiaohua Jin; Traian S Lupu; Bassel Beitinjaneh; Jacob Grand; Attila Kovacs; Nandakumar Sambandam; Anthony J Muslin
Journal: Circ Res Date: 2010-04-01 Impact factor: 17.367

4. HSP70 and GRP78 induced by endothelin-1 pretreatment enhance tolerance to hypoxia in cultured neonatal rat cardiomyocytes.

Authors: Yan-Xia Pan; Li Lin; An-Jing Ren; Xiu-Jie Pan; Hong Chen; Chao-Shu Tang; Wen-Jun Yuan
Journal: J Cardiovasc Pharmacol Date: 2004-11 Impact factor: 3.105

5. Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion.

Authors: Jianping Tao; Wei Zhu; Yapeng Li; Ping Xin; Jing Li; Mingya Liu; Jingbo Li; Andrew N Redington; Meng Wei
Journal: Am J Physiol Heart Circ Physiol Date: 2011-07-29 Impact factor: 4.733

6. Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.

Authors: Ge Gao; An Xie; Shu-Ching Huang; Anyu Zhou; Jianhua Zhang; Amanda M Herman; Sassan Ghassemzadeh; Euy-Myoung Jeong; Srinivasan Kasturirangan; Mihai Raicu; Michael A Sobieski; Geetha Bhat; Antone Tatooles; Edward J Benz; Timothy J Kamp; Samuel C Dudley
Journal: Circulation Date: 2011-08-22 Impact factor: 29.690

7. Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6.

Authors: Joshua J Martindale; Rayne Fernandez; Donna Thuerauf; Ross Whittaker; Natalie Gude; Mark A Sussman; Christopher C Glembotski
Journal: Circ Res Date: 2006-04-06 Impact factor: 17.367

8. PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress.

Authors: Philip Nickson; Ambrus Toth; Peter Erhardt
Journal: Cardiovasc Res Date: 2006-10-06 Impact factor: 10.787

9. PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.

Authors: Koji Isodono; Tomosaburo Takahashi; Hiroko Imoto; Naohiko Nakanishi; Takehiro Ogata; Satoshi Asada; Atsuo Adachi; Tomomi Ueyama; Hidemasa Oh; Hiroaki Matsubara
Journal: PLoS One Date: 2010-03-18 Impact factor: 3.240

10. Unfolded protein response regulates cardiac sodium current in systolic human heart failure.

Authors: Ge Gao; An Xie; Jianhua Zhang; Amanda M Herman; Euy-Myoung Jeong; Lianzhi Gu; Man Liu; Kai-Chien Yang; Timothy J Kamp; Samuel C Dudley
Journal: Circ Arrhythm Electrophysiol Date: 2013-09-13

7 in total

Review 1. Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias.

Authors: Man Liu; Gyeoung-Jin Kang; Samuel C Dudley
Journal: Trends Mol Med Date: 2022-04-10 Impact factor: 15.272

Review 2. Genetic, clinical, molecular, and pathogenic aspects of the South Asian-specific polymorphic MYBPC3^Δ25bp variant.

Authors: Mohammed Arif; Pooneh Nabavizadeh; Taejeong Song; Darshini Desai; Rohit Singh; Sholeh Bazrafshan; Mohit Kumar; Yigang Wang; Richard J Gilbert; Perundurai S Dhandapany; Richard C Becker; Evangelia G Kranias; Sakthivel Sadayappan
Journal: Biophys Rev Date: 2020-07-12

3. Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes.

Authors: Man Liu; Guangbin Shi; Anyu Zhou; Cassady E Rupert; Kareen L K Coulombe; Samuel C Dudley
Journal: J Mol Cell Cardiol Date: 2018-02-21 Impact factor: 5.000

Targeting the unfolded protein response in heart diseases.

1. Plasma cell differentiation requires the transcription factor XBP-1.

2. Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia.

3. TRB3 function in cardiac endoplasmic reticulum stress.

4. HSP70 and GRP78 induced by endothelin-1 pretreatment enhance tolerance to hypoxia in cultured neonatal rat cardiomyocytes.

5. Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion.

6. Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.

7. Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6.

8. PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress.

9. PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.

10. Unfolded protein response regulates cardiac sodium current in systolic human heart failure.

Review 1. Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias.

Review 2. Genetic, clinical, molecular, and pathogenic aspects of the South Asian-specific polymorphic MYBPC3^Δ25bp variant.

3. Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes.

Review 4. Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases.

Review 5. Lipotoxicity: a driver of heart failure with preserved ejection fraction?

6. Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction.

Review 7. The role of the unfolded protein response in arrhythmias.

Review 1. Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias.

Review 2. Genetic, clinical, molecular, and pathogenic aspects of the South Asian-specific polymorphic MYBPC3Δ25bp variant.

Review 4. Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases.

Review 5. Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Review 7. The role of the unfolded protein response in arrhythmias.

Review 2. Genetic, clinical, molecular, and pathogenic aspects of the South Asian-specific polymorphic MYBPC3^Δ25bp variant.