| Literature DB >> 2486523 |
F T Silveira, R Lainson, J J Shaw, L M Garcez, A A Souza, R R Braga, E A Ishikawa.
Abstract
The susceptibility of the monkey Cebus apella (Cebidae) to experimental infection by Leishmania (Viannia) lainsoni has been investigated. For this purpose, five young monkeys, 2 males and 3 females, were intradermally, inoculated, in eight different places along the dorsal surface of the tail with 3 x 10(6) promastigotes of the parasite (MHOM/BR/81/M6426, Benevides, Pará), from stationary phase culture in Difco B45 medium. After inoculations, infection in the monkeys was indicated by the presence of amastigotes in the skin lesions produced in these animals at the points of inoculation, confirming the susceptibility of the monkey Cebus apella to experimental infection by Leishmania lainsoni, with an infection period of four months. This represents a suitable period for testing antileishmanial drugs or studying the pathogenesis of the disease caused by this parasite.Entities:
Mesh:
Year: 1989 PMID: 2486523 DOI: 10.1590/s0037-86821989000300003
Source DB: PubMed Journal: Rev Soc Bras Med Trop ISSN: 0037-8682 Impact factor: 1.581