Literature DB >> 24864040

The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments.

C Tony Liu1, John W Tomsho2, Stephen J Benkovic3.   

Abstract

Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Benzoboroxole; Benzoxaborole; Boronic acid; Oxaborole; Sulfenic acid

Mesh:

Substances:

Year:  2014        PMID: 24864040     DOI: 10.1016/j.bmc.2014.04.065

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  24 in total

Review 1.  Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents.

Authors:  Panpan Zhang; Shutao Ma
Journal:  Medchemcomm       Date:  2019-05-27       Impact factor: 3.597

2.  Synthesis and evaluation of functionalized benzoboroxoles as potential anti-tuberculosis agents.

Authors:  Mohammad A Alam; Kriti Arora; Shirisha Gurrapu; Sravan K Jonnalagadda; Grady L Nelson; Paul Kiprof; Subash C Jonnalagadda; Venkatram R Mereddy
Journal:  Tetrahedron       Date:  2016-03-17       Impact factor: 2.457

3.  A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water.

Authors:  Roshan W Gunasekara; Yan Zhao
Journal:  J Am Chem Soc       Date:  2017-01-03       Impact factor: 15.419

Review 4.  The Taxonomy of Covalent Inhibitors.

Authors:  Alfred Tuley; Walter Fast
Journal:  Biochemistry       Date:  2018-04-30       Impact factor: 3.162

5.  Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles.

Authors:  Katrien Van Bocxlaer; Eric Gaukel; Deirdre Hauser; Seong Hee Park; Sara Schock; Vanessa Yardley; Ryan Randolph; Jacob J Plattner; Tejal Merchant; Simon L Croft; Robert T Jacobs; Stephen A Wring
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

6.  Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.

Authors:  Adèle Larcher; Alessio Nocentini; Claudiu T Supuran; Jean-Yves Winum; Arie van der Lee; Jean-Jacques Vasseur; Danielle Laurencin; Michael Smietana
Journal:  ACS Med Chem Lett       Date:  2019-07-11       Impact factor: 4.345

7.  Characterization of the Dynamic Equilibrium between Closed and Open Forms of the Benzoxaborole Pharmacophore.

Authors:  Sergey Vshyvenko; Marissa L Clapson; Itaru Suzuki; Dennis G Hall
Journal:  ACS Med Chem Lett       Date:  2016-09-21       Impact factor: 4.345

8.  Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer.

Authors:  Xinglin Li; Shanchao Wu; Guoqiang Dong; Shuqiang Chen; Zonglin Ma; Dan Liu; Chunquan Sheng
Journal:  ACS Med Chem Lett       Date:  2020-02-28       Impact factor: 4.345

9.  Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles.

Authors:  Scott J Barraza; Scott E Denmark
Journal:  J Am Chem Soc       Date:  2018-05-15       Impact factor: 15.419

10.  Adsorption of benzoxaboroles on hydroxyapatite phases.

Authors:  Marie-Alix Pizzoccaro; Ondrej Nikel; Saad Sene; Coralie Philippe; P Hubert Mutin; Sylvie Bégu; Deepak Vashishth; Danielle Laurencin
Journal:  Acta Biomater       Date:  2016-06-06       Impact factor: 8.947

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