Anne Tamigniau1, Pierre Wallemacq1, Diane Maisin2. 1. Laboratory of Clinical Chemistry, Saint-Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium. 2. Laboratory of Clinical Chemistry, Saint-Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium. Electronic address: diane.maisin@uclouvain.be.
Abstract
OBJECTIVES: Carbohydrate-deficient transferrin is a well-known biomarker widely used for detection of chronic excessive alcohol intake. However, under certain clinical conditions particularly frequently met amongst heavy drinkers (steatosis, fibrosis, cirrhosis…), it isn't a reliable biomarker. In this study, we tried to find additional biomarkers to CDT in order to improve detection of chronic excessive alcohol intake. DESIGN AND METHODS: We conducted a retrospective cohort study from December 2007 to December 2009. We focused mainly on three different groups: heavy drinking patients with active alcohol consumption (n=243), cirrhotic patients (abstinent patients and non alcoholic cirrhosis, n=44) and control group (n=85). RESULTS: In our study, CDT showed a poor sensitivity for diagnosis of heavy drinking patients (around 63%, and even lower) for cirrhotic patients and patients at advanced stage of fibrosis. Combination of CDT with trisialotransferrin enabled to improve significantly sensitivity and specificity (p-value AUC ROC<0.001). When adding mean corpuscular volume and gamma-glutamyltransferase to this first combination, performances were even better (p-value<0.001). This second cluster enabled to make a statistically significant difference between cirrhotic patients with active alcohol consumption compared to abstinent cirrhotic patients and to non alcoholic cirrhotic patients (p-value<0.001). CONCLUSION: From our study, trisialotransferrin seems to be a useful additional biomarker to CDT in order to improve detection of chronic excessive alcohol intake.
OBJECTIVES:Carbohydrate-deficient transferrin is a well-known biomarker widely used for detection of chronic excessive alcohol intake. However, under certain clinical conditions particularly frequently met amongst heavy drinkers (steatosis, fibrosis, cirrhosis…), it isn't a reliable biomarker. In this study, we tried to find additional biomarkers to CDT in order to improve detection of chronic excessive alcohol intake. DESIGN AND METHODS: We conducted a retrospective cohort study from December 2007 to December 2009. We focused mainly on three different groups: heavy drinking patients with active alcohol consumption (n=243), cirrhoticpatients (abstinent patients and non alcoholic cirrhosis, n=44) and control group (n=85). RESULTS: In our study, CDT showed a poor sensitivity for diagnosis of heavy drinking patients (around 63%, and even lower) for cirrhoticpatients and patients at advanced stage of fibrosis. Combination of CDT with trisialotransferrin enabled to improve significantly sensitivity and specificity (p-value AUC ROC<0.001). When adding mean corpuscular volume and gamma-glutamyltransferase to this first combination, performances were even better (p-value<0.001). This second cluster enabled to make a statistically significant difference between cirrhoticpatients with active alcohol consumption compared to abstinent cirrhoticpatients and to non alcoholic cirrhoticpatients (p-value<0.001). CONCLUSION: From our study, trisialotransferrin seems to be a useful additional biomarker to CDT in order to improve detection of chronic excessive alcohol intake.
Authors: Janique Arnts; Benedict T K Vanlerberghe; Sylvia Roozen; Cleo L Crunelle; Ad A M Masclee; Steven W M Olde-Damink; Ron M A Heeren; Alexander van Nuijs; Hugo Neels; Frederik Nevens; Jef Verbeek Journal: Alcohol Clin Exp Res Date: 2020-12-25 Impact factor: 3.455