José Luis Calvo-Guirado1, Miguel Garces2,3, Rafael Arcesio Delgado-Ruiz4, Maria P Ramirez Fernandez1, Eduard Ferres-Amat5, Georgios E Romanos6. 1. General & Implant Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. 2. Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. 3. National University of San Juan, San Juan, Argentine. 4. Department of Prosthodontics and Digital Technology, Stony Brook University, School of Dental Medicine, Stony Brook, NY, USA. 5. International University of Catalonia, Barcelona, Spain. 6. Department of Dental Medicine, Stony Brook University, School of Dental Medicine, Stony Brook, NY, USA.
Abstract
OBJECTIVE: The aim of this study was to assess the bone regeneration of critical size defects in rabbit calvarias filled with β-TCP doped with silicon. MATERIALS AND METHODS: Twenty-one New Zealand rabbits were used in this study. Two critical size defects were created in the parietal bones. Three experimental groups were evaluated: Test A (HA/β-TCP granules alone), Test B (HA/β-TCP granules plus 3% silicon), Control (empty defect). The animals were sacrificed at 8 and 12 weeks. Evaluation was performed by μCT analysis and histomorphometry. RESULTS: μCT evaluation showed higher volume reduction in Test A group compared with Test B (P < 0.05). The Test B group showed the highest values for cortical closure and bone formation around the particles, followed by Test A and controls (P < 0.05). CONCLUSIONS: Within the limitations of this animal study, it can be concluded that HA/β-TCP plus 3% silicon increases bone formation in critical size defects in rabbit calvarias, and the incorporation of 3% silicon reduces the resorption rate of the HA/β-TCP granules.
OBJECTIVE: The aim of this study was to assess the bone regeneration of critical size defects in rabbit calvarias filled with β-TCP doped with silicon. MATERIALS AND METHODS: Twenty-one New Zealand rabbits were used in this study. Two critical size defects were created in the parietal bones. Three experimental groups were evaluated: Test A (HA/β-TCP granules alone), Test B (HA/β-TCP granules plus 3% silicon), Control (empty defect). The animals were sacrificed at 8 and 12 weeks. Evaluation was performed by μCT analysis and histomorphometry. RESULTS: μCT evaluation showed higher volume reduction in Test A group compared with Test B (P < 0.05). The Test B group showed the highest values for cortical closure and bone formation around the particles, followed by Test A and controls (P < 0.05). CONCLUSIONS: Within the limitations of this animal study, it can be concluded that HA/β-TCP plus 3% silicon increases bone formation in critical size defects in rabbit calvarias, and the incorporation of 3% silicon reduces the resorption rate of the HA/β-TCP granules.