Di-Fan Zhu1, Yin Nian2, Hai-Yan Wang2, Zhi-Run Zhang2, Yan-Bo Song2, Rong-Tao Li3, Ming-Hua Qiu4. 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650050, China; State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. 2. State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. 3. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650050, China. 4. State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: mhchiu@mail.kib.ac.cn.
Abstract
AIM: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida. METHOD: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography (HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods. RESULTS: Five 9, 19-cycloartane triterpenes, (3β, 12β, 15α, 24R)-12, 2'-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside (1), actein (2), 23-epi-26-deoxyactein (3), asiaticoside B (4), and 12β-hydroxycimigenol (5) were isolated from the roots of Cimicifuga foetida. CONCLUSION: Compound 1 is a new triterpene with two acetoxy groups at C-2' and C-12.
AIM: To study the 9, 19-cycloartanetriterpenes from the roots of Cimicifuga foetida. METHOD: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography (HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods. RESULTS: Five 9, 19-cycloartanetriterpenes, (3β, 12β, 15α, 24R)-12, 2'-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside (1), actein (2), 23-epi-26-deoxyactein (3), asiaticoside B (4), and 12β-hydroxycimigenol (5) were isolated from the roots of Cimicifuga foetida. CONCLUSION: Compound 1 is a new triterpene with two acetoxy groups at C-2' and C-12.