Literature DB >> 24862864

L-citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants.

Candice D Fike1, Marshall Summar, Judy L Aschner.   

Abstract

UNLABELLED: Effective therapies are urgently needed for infants with forms of pulmonary hypertension that develop or persist beyond the first week of life. The L-arginine nitric oxide (NO) precursor, L-citrulline, improves NO signalling and ameliorates pulmonary hypertension in newborn animals. In vitro studies demonstrate that manipulating L-citrulline transport alters NO production.
CONCLUSION: Strategies that increase the supply and transport of L-citrulline merit pursuit as novel approaches to managing infants with chronic, progressive pulmonary hypertension. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Bronchopulmonary dysplasia; Nitric oxide; Oxidative stress; Premature infants; Pulmonary hypertension

Mesh：

Substances：

Year:  2014        PMID： 24862864      PMCID： PMC4209175          DOI： 10.1111/apa.12707

Source DB:  PubMed          Journal:  Acta Paediatr        ISSN： 0803-5253            Impact factor:   2.299


  63 in total

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2.  Neonatal pulmonary hypertension--urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function.

Authors:  D L Pearson; S Dawling; W F Walsh; J L Haines; B W Christman; A Bazyk; N Scott; M L Summar
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3.  Hypoxic upregulation of arginase II in human lung endothelial cells.

Authors:  Karina Krotova; Jawaharlal M Patel; Edward R Block; Sergey Zharikov
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5.  Prolonged hypoxia augments L-citrulline transport by system A in the newborn piglet pulmonary circulation.

Authors:  Candice D Fike; Marta Sidoryk-Wegrzynowicz; Michael Aschner; Marshall Summar; Lawrence S Prince; Gary Cunningham; Mark Kaplowitz; Yongmei Zhang; Judy L Aschner
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6.  Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension.

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Review 5.  Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate.

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6.  L-citrulline supplementation in the treatment of pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infant: A case report.

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8.  Metabolomic profiling of human pluripotent stem cell differentiation into lung progenitors.

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9.  Identification of Potential Metabolic Markers of Hypertension in Chinese Children.

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  9 in total

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