INTRODUCTION: Muscle pathology in Duchenne muscular dystrophy (DMD) can be quantified using ultrasound by measuring either the amplitudes of sound-waves scattered back from the tissue [quantitative backscatter analysis (QBA)] or by measuring these backscattered amplitudes after compression into grayscale levels (GSL) obtained from the images. METHODS: We measured and compared QBA and GSL from 6 muscles of 25 boys with DMD and 25 healthy subjects, aged 2-14 years, with age and, in DMD, with function (North Star Ambulatory Assessment). RESULTS: Both QBA and GSL were measured reliably (intraclass correlation ≥ 0.87) and were higher in DMD than controls (P < 0.0001). In DMD, average QBA and GSL measured from superficial regions of muscle increased (rho ≥ 0.47, P < 0.05) with both higher age and worse function; in contrast, GSL measured from whole regions of muscle did not. CONCLUSIONS: QBA and GSL measured from superficial regions of muscle can similarly quantify muscle pathology in DMD.
INTRODUCTION: Muscle pathology in Duchenne muscular dystrophy (DMD) can be quantified using ultrasound by measuring either the amplitudes of sound-waves scattered back from the tissue [quantitative backscatter analysis (QBA)] or by measuring these backscattered amplitudes after compression into grayscale levels (GSL) obtained from the images. METHODS: We measured and compared QBA and GSL from 6 muscles of 25 boys with DMD and 25 healthy subjects, aged 2-14 years, with age and, in DMD, with function (North Star Ambulatory Assessment). RESULTS: Both QBA and GSL were measured reliably (intraclass correlation ≥ 0.87) and were higher in DMD than controls (P < 0.0001). In DMD, average QBA and GSL measured from superficial regions of muscle increased (rho ≥ 0.47, P < 0.05) with both higher age and worse function; in contrast, GSL measured from whole regions of muscle did not. CONCLUSIONS:QBA and GSL measured from superficial regions of muscle can similarly quantify muscle pathology in DMD.
Authors: Sigrid Pillen; Ramon O Tak; Machiel J Zwarts; Martin M Y Lammens; Kiek N Verrijp; Ilse M P Arts; Jeroen A van der Laak; Peter M Hoogerbrugge; Baziel G M van Engelen; Aad Verrips Journal: Ultrasound Med Biol Date: 2008-12-10 Impact factor: 2.998
Authors: Merel Jansen; Nens van Alfen; Maria W G Nijhuis van der Sanden; Johannes P van Dijk; Sigrid Pillen; Imelda J M de Groot Journal: Neuromuscul Disord Date: 2011-11-30 Impact factor: 4.296
Authors: E S Mazzone; S Messina; G Vasco; M Main; M Eagle; A D'Amico; L Doglio; L Politano; F Cavallaro; S Frosini; L Bello; F Magri; A Corlatti; E Zucchini; B Brancalion; F Rossi; M Ferretti; M G Motta; M R Cecio; A Berardinelli; P Alfieri; T Mongini; A Pini; G Astrea; R Battini; G Comi; E Pegoraro; L Morandi; M Pane; C Angelini; C Bruno; M Villanova; G Vita; M A Donati; E Bertini; E Mercuri Journal: Neuromuscul Disord Date: 2009-06-23 Impact factor: 4.296
Authors: Sisir Koppaka; Irina Shklyar; Seward B Rutkove; Basil T Darras; Brian W Anthony; Craig M Zaidman; Jim S Wu Journal: J Ultrasound Med Date: 2016-07-14 Impact factor: 2.153
Authors: Craig M Zaidman; Jim S Wu; Kush Kapur; Amy Pasternak; Lavanya Madabusi; Sung Yim; Adam Pacheck; Heather Szelag; Tim Harrington; Basil T Darras; Seward B Rutkove Journal: Ann Neurol Date: 2017-05-04 Impact factor: 10.422
Authors: Bhaskar Roy; Basil T Darras; Craig M Zaidman; Jim S Wu; Kush Kapur; Seward B Rutkove Journal: Clin Neurophysiol Date: 2019-02-12 Impact factor: 3.708
Authors: James A Loehr; Gary R Stinnett; Mayra Hernández-Rivera; Wesley T Roten; Lon J Wilson; Robia G Pautler; George G Rodney Journal: J Physiol Date: 2016-10-17 Impact factor: 5.182
Authors: C E McIlduff; M G Martucci; C Shin; K Qi; A K Pacheck; H Gutierrez; M Mortreux; S B Rutkove Journal: Clin Neurophysiol Date: 2020-07-17 Impact factor: 3.708