| Literature DB >> 24862067 |
Li-Shian Shi1, Chao-Hsuan Wu2, Te-Chun Yang3, Chen-Wen Yao4, Hang-Ching Lin5, Wen-Liang Chang6.
Abstract
In this study, 4 new triterpenoids-3β- acetoxy-olean-11-en,28,13β-olide (1), 3β- acetoxy-11α,12α-epoxy-olean-28,13β-olide (2), 19α-epi-betulin (3), and 20, 28-epoxy-17β,19β-lupan-3β-ol (4)-and 12 known compounds, were isolated from the root bark of Hibiscus syriacus L. by using acetone extraction. Their structures were characterized by extensive spectroscopic analysis. To investigate cytotoxicity, A549 human lung cancer cells were exposed to the extract and the compounds identified from it. Significantly reduced cell viability was observed with betulin-3-caffeate (12) (IC50, 4.3 μM). The results of this study indicate that betulin-3-caffeate (12) identified from H. syriacus L. may warrant further investigation for potential as anticancer therapies.Entities:
Keywords: 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (PubChem CID: 64965); Anticancer; Cytotoxicity; Hibiscus syriacus L; Triterpenoid; betulin (PubChem CID: 72326); betulin-3-caffeate (PubChem CID: 10153267); betulinic acid (PubChem CID: 64971); betulinic acid-3-caffeate (PubChem CID: 6439576); lupeol (PubChem CID: 73040); oleanolic acid (PubChem CID: 10494); oleanolic acid-3-acetate (PubChem CID: 151202); β-sitosterol (PubChem CID: 222284); β-sitosterol-3-O-β-D-glucoside (PubChem CID: 70699351)
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Year: 2014 PMID： 24862067 DOI： 10.1016/j.fitote.2014.05.006
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882