| Literature DB >> 24861945 |
María Concepción Izquierdo1, Catalina Martin-Cleary2, Beatriz Fernandez-Fernandez3, Usama Elewa4, María D Sanchez-Niño5, Juan Jesús Carrero6, Alberto Ortiz7.
Abstract
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. Conflicting results were reported for experimental cardiovascular injury. High circulating CXCL16 levels are associated to human kidney and cardiovascular disease and urinary CXCL16 may increase in kidney injury. In conclusion, mounting evidence suggests a role of CXCL16 in kidney and cardiovascular disease. However, a better understanding is still required before exploring CXCL16 targeting in the clinic.Entities:
Keywords: Atherosclerosis; Chemokine; Chronic kidney disease; Inflammation
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Year: 2014 PMID： 24861945 DOI： 10.1016/j.cytogfr.2014.04.002
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638