OBJECTIVE: To evaluate gestational age-dependent changes in the T2 relaxation time in normal murine placentas in vivo. The role of susceptibility-weighted imaging (SWI) in visualization of the murine fetal anatomy was also elucidated. METHODS: Timed-pregnant CD-1 mice at gestational day (GD) 12 and GD17 underwent magnetic resonance imaging. Multi-echo spin echo and SWI data were acquired. The placental T2 values on GD12 and GD17 were quantified. To account for the influence of systemic maternal physiological factors on placental perfusion, maternal muscle was used as a reference for T2 normalization. A linear mixed-effects model was used to fit the normalized T2 values, and the significance of the coefficients was tested. Fetal SWI images were processed and reviewed for venous vasculature and skeletal structures. RESULTS: The average placental T2 value decreased significantly on GD17 (40.17 ± 4.10 ms) compared to the value on GD12 (55.78 ± 8.13 ms). The difference in normalized T2 values also remained significant (p = 0.001). Using SWI, major fetal venous structures like the cardinal vein, the subcardinal vein, and the portal vein were visualized on GD12. In addition, fetal skeletal structures could also be discerned on GD17. CONCLUSION: The T2 value of a normal murine placenta decreases with advancing gestation. SWI provided clear visualization of the fetal venous vasculature and bony structures.
OBJECTIVE: To evaluate gestational age-dependent changes in the T2 relaxation time in normal murine placentas in vivo. The role of susceptibility-weighted imaging (SWI) in visualization of the murine fetal anatomy was also elucidated. METHODS: Timed-pregnant CD-1mice at gestational day (GD) 12 and GD17 underwent magnetic resonance imaging. Multi-echo spin echo and SWI data were acquired. The placental T2 values on GD12 and GD17 were quantified. To account for the influence of systemic maternal physiological factors on placental perfusion, maternal muscle was used as a reference for T2 normalization. A linear mixed-effects model was used to fit the normalized T2 values, and the significance of the coefficients was tested. Fetal SWI images were processed and reviewed for venous vasculature and skeletal structures. RESULTS: The average placental T2 value decreased significantly on GD17 (40.17 ± 4.10 ms) compared to the value on GD12 (55.78 ± 8.13 ms). The difference in normalized T2 values also remained significant (p = 0.001). Using SWI, major fetal venous structures like the cardinal vein, the subcardinal vein, and the portal vein were visualized on GD12. In addition, fetal skeletal structures could also be discerned on GD17. CONCLUSION: The T2 value of a normal murine placenta decreases with advancing gestation. SWI provided clear visualization of the fetal venous vasculature and bony structures.
Authors: J R Reichenbach; M Barth; E M Haacke; M Klarhöfer; W A Kaiser; E Moser Journal: J Comput Assist Tomogr Date: 2000 Nov-Dec Impact factor: 1.826
Authors: M Damodaram; L Story; E Eixarch; A Patel; A McGuinness; J Allsop; J Wyatt-Ashmead; S Kumar; M Rutherford Journal: Placenta Date: 2010-03-29 Impact factor: 3.481
Authors: Nandor Gabor Than; Roberto Romero; Morris Goodman; Amy Weckle; Jun Xing; Zhong Dong; Yi Xu; Federica Tarquini; Andras Szilagyi; Peter Gal; Zhuocheng Hou; Adi L Tarca; Chong Jai Kim; Jung-Sun Kim; Saied Haidarian; Monica Uddin; Hans Bohn; Kurt Benirschke; Joaquin Santolaya-Forgas; Lawrence I Grossman; Offer Erez; Sonia S Hassan; Peter Zavodszky; Zoltan Papp; Derek E Wildman Journal: Proc Natl Acad Sci U S A Date: 2009-06-02 Impact factor: 11.205
Authors: Cesar A Berrios-Otero; Youssef Zaim Wadghiri; Brian J Nieman; Alexandra L Joyner; Daniel H Turnbull Journal: Magn Reson Med Date: 2009-12 Impact factor: 4.668
Authors: Esra Abaci Turk; Jeffrey N Stout; Christopher Ha; Jie Luo; Borjan Gagoski; Filiz Yetisir; Polina Golland; Lawrence L Wald; Elfar Adalsteinsson; Julian N Robinson; Drucilla J Roberts; William H Barth; P Ellen Grant Journal: Top Magn Reson Imaging Date: 2019-10
Authors: Gabor Szalai; Roberto Romero; Tinnakorn Chaiworapongsa; Yi Xu; Bing Wang; Hyunyoung Ahn; Zhonghui Xu; Po Jen Chiang; Birgitta Sundell; Rona Wang; Yang Jiang; Olesya Plazyo; Mary Olive; Adi L Tarca; Zhong Dong; Faisal Qureshi; Zoltan Papp; Sonia S Hassan; Edgar Hernandez-Andrade; Nandor Gabor Than Journal: PLoS One Date: 2015-04-10 Impact factor: 3.240