José Roberto Lambertucci1, Thiago André Fidelis1, Thiago Almeida Pereira2, Paulo Marcos Zech Coelho3, Neuza Araujo3, Márcia Maria de Souza4, Geraldo Brasileiro Filho2, Fausto Edmundo Lima Pereira5, Carlos Mauricio Antunes6. 1. Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BRAZIL. 2. Departamento de Anatomia Patológica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BRAZIL. 3. Centro de Pesquisas René-Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, BRAZIL. 4. Durham, Durham, North Carolin, USA. 5. Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil. 6. Santa Casa de Misericórdia de Belo Horizonte, Minas Gerais, Belo Horizonte, MG, BRAZIL.
Abstract
INTRODUCTION: Human neuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. METHODS: In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. RESULTS: S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. CONCLUSIONS: This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S. mansoni. An investigation of experimental neuroschistosomiasis is now feasible.
INTRODUCTION:Humanneuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. METHODS: In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. RESULTS:S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. CONCLUSIONS: This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S. mansoni. An investigation of experimental neuroschistosomiasis is now feasible.
Authors: Mohamed A Dkhil; Amira A Bauomy; Marwa S M Diab; Rizwan Wahab; Denis Delic; Saleh Al-Quraishy Journal: Parasitol Res Date: 2015-07-01 Impact factor: 2.289
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