BACKGROUND: According to the field effect theory, by detecting microvasculature changes such as early increase in blood supply (EIBS) in the surrounding tissue, neoplastic lesions can be identified from a distance. OBJECTIVE: To determine the feasibility and efficacy of a fiberoptic probe containing novel polarization gating spectroscopy technology to identify patients with pancreatic adenocarcinoma (PAC) by the field effect theory. DESIGN: Prospective cohort (pilot) study. SETTING: Outpatient tertiary care center. PATIENTS: Adult (≥ 18 years) patients undergoing EGD-EUS were screened. Patients with PAC were included in the "cancer" group and patients without PAC were included in the "control" group. We excluded patients with other known malignancies and gastroduodenal premalignant lesions. INTERVENTIONS AND MAIN OUTCOME MEASURES: Spectroscopic measurements of EIBS variables, such as deoxyhemoglobin concentration (DHb) and mean blood vessel radius (BVR), were obtained from 5 periampullary locations. The Mann-Whitney rank sum test was used for the statistical analysis (P ≤ .05). RESULTS: Fourteen patients (mean age 72 years, 79% male) in the cancer group and 15 patients (mean age 63 years, 60% male) in the control group were included in the final analysis. At the ampullary site, both DHb (P = .001) and BVR (P = .03) were higher in PAC patients than in the control subjects. The DHb alone (92% sensitivity, 86% specificity) or in combination with BVR (92% sensitivity, 79% specificity) can differentiate PAC from control subjects with high accuracy. LIMITATIONS: Small sample size, unmatched control subjects. CONCLUSIONS: Spectroscopic measurements of EIBS by fiberoptic probes are feasible. Preliminary evidence suggests that in vivo measurement of normal-appearing duodenal tissue can differentiate PAC patients from a distance with high accuracy.
BACKGROUND: According to the field effect theory, by detecting microvasculature changes such as early increase in blood supply (EIBS) in the surrounding tissue, neoplastic lesions can be identified from a distance. OBJECTIVE: To determine the feasibility and efficacy of a fiberoptic probe containing novel polarization gating spectroscopy technology to identify patients with pancreatic adenocarcinoma (PAC) by the field effect theory. DESIGN: Prospective cohort (pilot) study. SETTING:Outpatient tertiary care center. PATIENTS: Adult (≥ 18 years) patients undergoing EGD-EUS were screened. Patients with PAC were included in the "cancer" group and patients without PAC were included in the "control" group. We excluded patients with other known malignancies and gastroduodenal premalignant lesions. INTERVENTIONS AND MAIN OUTCOME MEASURES: Spectroscopic measurements of EIBS variables, such as deoxyhemoglobin concentration (DHb) and mean blood vessel radius (BVR), were obtained from 5 periampullary locations. The Mann-Whitney rank sum test was used for the statistical analysis (P ≤ .05). RESULTS: Fourteen patients (mean age 72 years, 79% male) in the cancer group and 15 patients (mean age 63 years, 60% male) in the control group were included in the final analysis. At the ampullary site, both DHb (P = .001) and BVR (P = .03) were higher in PACpatients than in the control subjects. The DHb alone (92% sensitivity, 86% specificity) or in combination with BVR (92% sensitivity, 79% specificity) can differentiate PAC from control subjects with high accuracy. LIMITATIONS: Small sample size, unmatched control subjects. CONCLUSIONS: Spectroscopic measurements of EIBS by fiberoptic probes are feasible. Preliminary evidence suggests that in vivo measurement of normal-appearing duodenal tissue can differentiate PACpatients from a distance with high accuracy.
Authors: Elizabeth C Verna; Caroline Hwang; Peter D Stevens; Heidrun Rotterdam; Stavros N Stavropoulos; Carolyn D Sy; Martin A Prince; Wendy K Chung; Robert L Fine; John A Chabot; Harold Frucht Journal: Clin Cancer Res Date: 2010-09-28 Impact factor: 12.531
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Authors: Lanlan Shen; Yutaka Kondo; Gary L Rosner; Lianchun Xiao; Natalie Supunpong Hernandez; Jill Vilaythong; P Scott Houlihan; Robert S Krouse; Anil R Prasad; Janine G Einspahr; Julie Buckmeier; David S Alberts; Stanley R Hamilton; Jean-Pierre J Issa Journal: J Natl Cancer Inst Date: 2005-09-21 Impact factor: 13.506
Authors: Hemant K Roy; Yang Liu; Ramesh K Wali; Young L Kim; Alexei K Kromine; Michael J Goldberg; Vadim Backman Journal: Gastroenterology Date: 2004-04 Impact factor: 22.682
Authors: Hemant K Roy; Young L Kim; Yang Liu; Ramesh K Wali; Michael J Goldberg; Vladimir Turzhitsky; Jonathan Horwitz; Vadim Backman Journal: Clin Cancer Res Date: 2006-02-01 Impact factor: 12.531
Authors: Stephen Chad Kanick; David M McClatchy; Venkataramanan Krishnaswamy; Jonathan T Elliott; Keith D Paulsen; Brian W Pogue Journal: Biomed Opt Express Date: 2014-09-03 Impact factor: 3.732