| Literature DB >> 24859746 |
Lumei Liu1, Wenbin Wan2, Shijin Xia3, Bill Kalionis4, Yaming Li5.
Abstract
Increased Aβ clearance from brain is essential for restoring the pathological manifestation of Alzheimer's disease (AD) and attenuating the cognitive disorder. The blood-brain barrier (BBB) plays a critical role in maintaining homeostasis of the brain, and transporters e.g. P-glycoprotein (P-gp) are essential for Aβ clearance from the brain. In addition, the Wnt/β-catenin signaling pathway contributes to BBB formation, induction and maturation, and induces BBB function. Dysfunctional Wnt/β-catenin signaling in the BBB reveals the importance of this pathway, since this contributes to the neurodegeneration characteristic of AD. Based on the above evidence, we propose that targeting the canonical Wnt signaling pathway could be promising therapeutic approach for treatment of AD.Entities:
Keywords: Alzheimer’s disease; Blood–brain barrier; Central nervous system; Wnt/β-catenin signaling pathway; β-Amyloid
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Year: 2014 PMID： 24859746 DOI： 10.1016/j.neuint.2014.05.004
Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921