Mathew D Sorensen1, Ryan S Hsi2, Thomas Chi3, Nawar Shara4, Jean Wactawski-Wende5, Arnold J Kahn6, Hong Wang4, Lifang Hou7, Marshall L Stoller3. 1. Division of Urology, Department of Veterans Affairs Medical Center, and Department of Urology, Urological Research Outcomes Collaboration, University of Washington School of Medicine, Seattle, Washington. Electronic address: mathews@uw.edu. 2. Department of Urology, University of Washington School of Medicine, Seattle, Washington. 3. Department of Urology, University of California, San Francisco, San Francisco, California. 4. Department of Biostatistics and Epidemiology, Georgetown University, MedStar Health Research Institute, Hyattsville, Maryland. 5. Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York. 6. San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California. 7. Department of Preventive Medicine, Northwestern University, Chicago, Illinois.
Abstract
PURPOSE: We evaluated the relationship between dietary fiber, fruit and vegetable intake, and the risk of kidney stone formation. MATERIALS AND METHODS: Overall 83,922 postmenopausal women from the Women's Health Initiative observational study were included in the analysis and followed prospectively. Cox proportional hazards regression analyses were used to evaluate the associations between total dietary fiber, fruit and vegetable intake, and the risk of incident kidney stone formation, adjusting for nephrolithiasis risk factors (age, race/ethnicity, geographic region, diabetes mellitus, calcium supplementation, hormone therapy use, body mass index and calibrated caloric intake; and dietary water, sodium, animal protein and calcium intake). Women with a history of kidney stones (3,471) were analyzed separately. RESULTS: Mean age of the women was 64±7 years, 85% were white and 2,937 (3.5%) experienced a kidney stone in a median followup of 8 years. In women with no history of kidney stones higher total dietary fiber (6% to 26% decreased risk, p <0.001), greater fruit intake (12% to 25% decreased risk, p <0.001) and greater vegetable intake (9% to 22% decreased risk, p=0.002) were associated with a decreased risk of incident kidney stone formation in separate adjusted models. In women with a history of stones there were no significant protective effects of fiber, fruit or vegetable intake on the risk of kidney stone recurrence. CONCLUSIONS: Greater dietary intake of fiber, fruits and vegetables was associated with a reduced risk of incident kidney stones in postmenopausal women. The protective effects were independent of other known risk factors for kidney stones. In contrast, there was no reduction in risk in women with a history of stones.
PURPOSE: We evaluated the relationship between dietary fiber, fruit and vegetable intake, and the risk of kidney stone formation. MATERIALS AND METHODS: Overall 83,922 postmenopausal women from the Women's Health Initiative observational study were included in the analysis and followed prospectively. Cox proportional hazards regression analyses were used to evaluate the associations between total dietary fiber, fruit and vegetable intake, and the risk of incident kidney stone formation, adjusting for nephrolithiasis risk factors (age, race/ethnicity, geographic region, diabetes mellitus, calcium supplementation, hormone therapy use, body mass index and calibrated caloric intake; and dietary water, sodium, animal protein and calcium intake). Women with a history of kidney stones (3,471) were analyzed separately. RESULTS: Mean age of the women was 64±7 years, 85% were white and 2,937 (3.5%) experienced a kidney stone in a median followup of 8 years. In women with no history of kidney stones higher total dietary fiber (6% to 26% decreased risk, p <0.001), greater fruit intake (12% to 25% decreased risk, p <0.001) and greater vegetable intake (9% to 22% decreased risk, p=0.002) were associated with a decreased risk of incident kidney stone formation in separate adjusted models. In women with a history of stones there were no significant protective effects of fiber, fruit or vegetable intake on the risk of kidney stone recurrence. CONCLUSIONS: Greater dietary intake of fiber, fruits and vegetables was associated with a reduced risk of incident kidney stones in postmenopausal women. The protective effects were independent of other known risk factors for kidney stones. In contrast, there was no reduction in risk in women with a history of stones.
Authors: S W Lichtman; K Pisarska; E R Berman; M Pestone; H Dowling; E Offenbacher; H Weisel; S Heshka; D E Matthews; S B Heymsfield Journal: N Engl J Med Date: 1992-12-31 Impact factor: 91.245
Authors: Jacques E Rossouw; Garnet L Anderson; Ross L Prentice; Andrea Z LaCroix; Charles Kooperberg; Marcia L Stefanick; Rebecca D Jackson; Shirley A A Beresford; Barbara V Howard; Karen C Johnson; Jane Morley Kotchen; Judith Ockene Journal: JAMA Date: 2002-07-17 Impact factor: 56.272
Authors: Vincent Castiglione; Hans Pottel; John Charles Lieske; Pierre Lukas; Etienne Cavalier; Pierre Delanaye; Andrew David Rule Journal: J Nephrol Date: 2019-06-20 Impact factor: 3.902
Authors: Laura D Carbone; Kathleen M Hovey; Christopher A Andrews; Fridtjof Thomas; Mathew D Sorensen; Carolyn J Crandall; Nelson B Watts; Monique Bethel; Karen C Johnson Journal: J Bone Miner Res Date: 2015-07-14 Impact factor: 6.741
Authors: Adrian Rodriguez; Gary C Curhan; Giovanni Gambaro; Eric N Taylor; Pietro Manuel Ferraro Journal: Am J Clin Nutr Date: 2020-05-01 Impact factor: 7.045
Authors: Mayandi Sivaguru; Jessica J Saw; Elena M Wilson; John C Lieske; Amy E Krambeck; James C Williams; Michael F Romero; Kyle W Fouke; Matthew W Curtis; Jamie L Kear-Scott; Nicholas Chia; Bruce W Fouke Journal: Nat Rev Urol Date: 2021-05-24 Impact factor: 14.432