Literature DB >> 24859204

Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man.

Sandra Franco1, Cristina Tural2, Maria Nevot1, José Moltó2, Jürgen Kurt Rockstroh3, Bonaventura Clotet4, Miguel Angel Martinez5.   

Abstract

There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.
Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cirrhosis; Liver Disease; Transmission

Mesh：

Substances：

Year:  2014        PMID： 24859204     DOI： 10.1053/j.gastro.2014.05.010

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  25 in total

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Review 3.  Can Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine?

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6.  Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.

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8.  Is HIV still a special population for the treatment of hepatitis C?

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Journal:  AIDS       Date:  2016-07-31       Impact factor: 4.177

9.  Analysis of resistance-associated substitutions in acute hepatitis C virus infection by deep sequencing across six genotypes and three continents.

Authors:  A A Eltahla; C Rodrigo; B Betz-Stablein; J Grebely; T Applegate; F Luciani; J Schinkel; G J Dore; K Page; J Bruneau; M D Morris; A L Cox; A Y Kim; N H Shoukry; G M Lauer; L Maher; M Hellard; M Prins; A R Lloyd; R A Bull
Journal:  J Viral Hepat       Date:  2016-09-25       Impact factor: 3.728

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