Stephanie M Gorka1, Ashley A Huggins1, Daniel A Fitzgerald2, Brady D Nelson1, K Luan Phan3, Stewart A Shankman4. 1. University of Illinois - Chicago, Department of Psychology, 1007 West Harrison Street (M/C 285), Chicago, IL 60607, USA. 2. University of Illinois-Chicago, Department of Psychiatry, 1747 West Roosevelt Road, Chicago, IL 60608, USA. 3. University of Illinois - Chicago, Department of Psychology, 1007 West Harrison Street (M/C 285), Chicago, IL 60607, USA; University of Illinois-Chicago, Department of Psychiatry, 1747 West Roosevelt Road, Chicago, IL 60608, USA; Jesse Brown VA Medical Center, Mental Health Service Line, 820 S. Damen Avenue, Chicago, IL 60612, USA. 4. University of Illinois - Chicago, Department of Psychology, 1007 West Harrison Street (M/C 285), Chicago, IL 60607, USA. Electronic address: stewarts@uic.edu.
Abstract
BACKGROUND: One of the hallmark features of major depressive disorder (MDD) is reduced reward anticipation. There have been mixed findings in the literature as to whether reward anticipation deficits in MDD are related to diminished mesolimbic activation and/or enhanced dorsal anterior cingulate activation (dACC). One of the reasons for these mixed findings is that these studies have typically not addressed the role of comorbid anxiety, a class of disorders which frequently co-occur with depression and have a common neurobiology. METHODS: The aim of the current study was to examine group differences in neural responses to reward anticipation in 40 adults with either: (1) current MDD with no lifetime diagnosis of an anxiety disorder (MDD-only), (2) current MDD with comorbid panic disorder (MDD-PD), or (3) no lifetime diagnosis of psychopathology. All participants completed a passive slot machine task during a functional magnetic resonance imaging (fMRI) scan. RESULTS: Analyses indicated that there were no group differences in activation of mesolimbic reward regions; however, the MDD-only group exhibited greater dACC activation during the anticipation of rewards compared with the healthy controls and the comorbid MDD-PD group (who did not differ from each other). LIMITATIONS: The sample size was small which limits generalizability. CONCLUSIONS: These findings provide preliminary support for the role of hyperactive dACC functioning in reduced reward anticipation in MDD. They also indicate that comorbid anxiety may alter the association between MDD and neural responding to reward anticipation.
BACKGROUND: One of the hallmark features of major depressive disorder (MDD) is reduced reward anticipation. There have been mixed findings in the literature as to whether reward anticipation deficits in MDD are related to diminished mesolimbic activation and/or enhanced dorsal anterior cingulate activation (dACC). One of the reasons for these mixed findings is that these studies have typically not addressed the role of comorbid anxiety, a class of disorders which frequently co-occur with depression and have a common neurobiology. METHODS: The aim of the current study was to examine group differences in neural responses to reward anticipation in 40 adults with either: (1) current MDD with no lifetime diagnosis of an anxiety disorder (MDD-only), (2) current MDD with comorbid panic disorder (MDD-PD), or (3) no lifetime diagnosis of psychopathology. All participants completed a passive slot machine task during a functional magnetic resonance imaging (fMRI) scan. RESULTS: Analyses indicated that there were no group differences in activation of mesolimbic reward regions; however, the MDD-only group exhibited greater dACC activation during the anticipation of rewards compared with the healthy controls and the comorbid MDD-PD group (who did not differ from each other). LIMITATIONS: The sample size was small which limits generalizability. CONCLUSIONS: These findings provide preliminary support for the role of hyperactive dACC functioning in reduced reward anticipation in MDD. They also indicate that comorbid anxiety may alter the association between MDD and neural responding to reward anticipation.
Authors: Stewart A Shankman; Brady D Nelson; Casey Sarapas; E Jenna Robison-Andrew; Miranda L Campbell; Sarah E Altman; Sarah Kate McGowan; Andrea C Katz; Stephanie M Gorka Journal: J Abnorm Psychol Date: 2012-11-12
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Doreen Koretz; Kathleen R Merikangas; A John Rush; Ellen E Walters; Philip S Wang Journal: JAMA Date: 2003-06-18 Impact factor: 56.272
Authors: Jennifer L Stewart; Evan J White; Rayus Kuplicki; Elisabeth Akeman; Jerzy Bodurka; Yoon-Hee Cha; Justin S Feinstein; Sahib S Khalsa; Jonathan B Savitz; Teresa A Victor; Martin P Paulus; Robin L Aupperle Journal: J Affect Disord Date: 2020-05-11 Impact factor: 4.839
Authors: Hanna Keren; Georgia O'Callaghan; Pablo Vidal-Ribas; George A Buzzell; Melissa A Brotman; Ellen Leibenluft; Pedro M Pan; Liana Meffert; Ariela Kaiser; Selina Wolke; Daniel S Pine; Argyris Stringaris Journal: Am J Psychiatry Date: 2018-06-20 Impact factor: 18.112
Authors: Natania A Crane; Lisanne M Jenkins; Catherine Dion; Kortni K Meyers; Anne L Weldon; Laura B Gabriel; Sara J Walker; David T Hsu; Douglas C Noll; Heide Klumpp; K Luan Phan; Jon-Kar Zubieta; Scott A Langenecker Journal: Depress Anxiety Date: 2016-07-25 Impact factor: 6.505
Authors: Bei Zhang; Pan Lin; Huqing Shi; Dost Öngür; Randy P Auerbach; Xiaosheng Wang; Shuqiao Yao; Xiang Wang Journal: Brain Imaging Behav Date: 2016-09 Impact factor: 3.978