PURPOSE: To investigate the relationship between human papillomavirus (HPV) infection and prostatitis-related symptoms. MATERIALS AND METHODS: All young heterosexual patients with prostatitis-related symptoms attending the same Center from January 2005 to December 2010 were eligible for this case-control study. Sexually active asymptomatic men were considered as the control group. All subjects underwent clinical examination, Meares-Stamey test and DNA-HPV test. Patients with prostatitis-related symptoms and asymptomatic men were compared in terms of HPV prevalence. Moreover, multivariable Cox proportional hazards regression analysis was performed to determine the association between HPV infection and prostatitis-related symptoms. RESULTS: Overall, 814 out of 2,938 patients (27.7%) and 292 out of 1,081 controls (27.0%) proved positive to HPV. The HPV genotype distribution was as follows: HR-HPV 478 (43.3%), PHR-HPV 77 (6.9%), LR-HPV 187 (16.9%) and PNG-HPV 364 (32.9%). The most common HPV genotypes were: 6, 11, 16, 26, 51, 53 and 81. No difference was found between the two groups in terms of HPV infection (OR 1.03; 95% CI 0.88-1.22; p = 0.66). We noted a statistically significant increase in HPV infection over the period 2005 to 2010 (p < 0.001) in both groups. Moreover, we found a statistically significant increase in HPV 16 frequency from 2005 to 2010 (p = 0.002). CONCLUSIONS: This study highlights that prostatitis-like symptoms are unrelated to HPV infection. Secondary, we highlight the high prevalence of asymptomatic HPV infection among young heterosexual men.
PURPOSE: To investigate the relationship between human papillomavirus (HPV) infection and prostatitis-related symptoms. MATERIALS AND METHODS: All young heterosexual patients with prostatitis-related symptoms attending the same Center from January 2005 to December 2010 were eligible for this case-control study. Sexually active asymptomatic men were considered as the control group. All subjects underwent clinical examination, Meares-Stamey test and DNA-HPV test. Patients with prostatitis-related symptoms and asymptomatic men were compared in terms of HPV prevalence. Moreover, multivariable Cox proportional hazards regression analysis was performed to determine the association between HPV infection and prostatitis-related symptoms. RESULTS: Overall, 814 out of 2,938 patients (27.7%) and 292 out of 1,081 controls (27.0%) proved positive to HPV. The HPV genotype distribution was as follows: HR-HPV 478 (43.3%), PHR-HPV 77 (6.9%), LR-HPV 187 (16.9%) and PNG-HPV 364 (32.9%). The most common HPV genotypes were: 6, 11, 16, 26, 51, 53 and 81. No difference was found between the two groups in terms of HPV infection (OR 1.03; 95% CI 0.88-1.22; p = 0.66). We noted a statistically significant increase in HPV infection over the period 2005 to 2010 (p < 0.001) in both groups. Moreover, we found a statistically significant increase in HPV 16 frequency from 2005 to 2010 (p = 0.002). CONCLUSIONS: This study highlights that prostatitis-like symptoms are unrelated to HPV infection. Secondary, we highlight the high prevalence of asymptomatic HPV infection among young heterosexual men.
Authors: T Cai; G Perletti; F Meacci; V Magri; P Verze; A Palmieri; S Mazzoli; R Santi; G Nesi; V Mirone; R Bartoletti Journal: Eur J Clin Microbiol Infect Dis Date: 2016-01-11 Impact factor: 3.267
Authors: S La Vignera; R A Condorelli; R Cannarella; F Giacone; L Mongioi'; G Scalia; V Favilla; G I Russo; S Cimino; G Morgia; A E Calogero Journal: J Endocrinol Invest Date: 2019-06-04 Impact factor: 4.256
Authors: Fernando Nestor Facio; Maria Fernanda Warick Facio; Ana Clara Nagle Spessoto; Moacir Godoy; Hariel Tessaro; Ricardo Campos; Diego Zanatto; Marilia Calmon; Paula Rahal; Luís Cesar Fava Spessoto Journal: Cureus Date: 2022-02-06