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Literature DB >> 24856329

Insights from the worm: the C. elegans model for innate immunity.

Abstract

The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C. elegans recognizes and responds to viral, bacterial, and fungal infections. Components of the RNA interference machinery respond to viral infection, while highly conserved MAPK signaling pathways activate the innate immune response to bacterial infection. C. elegans has been particularly important for exploring the role of innate immunity in organismal stress resistance and the regulation of longevity. Also functions of neuronal sensing of infectious bacteria have recently been uncovered. Studies on nematode immunity can be instructive in exploring innate immune signaling in the absence of specialized immune cells and adaptive immunity.

Entities: Chemical

Keywords: Ancestral immunity; C. elegans; Host–pathogen interaction; Innate immunity

Mesh：

Substances：

Year: 2014 PMID： 24856329 PMCID： PMC4248339 DOI： 10.1016/j.smim.2014.04.005

Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130

74 in total

1. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.

Authors: Coleen T Murphy; Steven A McCarroll; Cornelia I Bargmann; Andrew Fraser; Ravi S Kamath; Julie Ahringer; Hao Li; Cynthia Kenyon
Journal: Nature Date: 2003-06-29 Impact factor: 49.962

2. Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening.

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Journal: EMBO J Date: 2003-04-01 Impact factor: 11.598

3. A simple model host for identifying Gram-positive virulence factors.

Authors: D A Garsin; C D Sifri; E Mylonakis; X Qin; K V Singh; B E Murray; S B Calderwood; F M Ausubel
Journal: Proc Natl Acad Sci U S A Date: 2001-09-04 Impact factor: 11.205

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Authors: Dennis H Kim; Nicole T Liberati; Tomoaki Mizuno; Hideki Inoue; Naoki Hisamoto; Kunihiro Matsumoto; Frederick M Ausubel
Journal: Proc Natl Acad Sci U S A Date: 2004-07-15 Impact factor: 11.205

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Authors: C Léopold Kurz; Jonathan J Ewbank
Journal: Nat Rev Genet Date: 2003-05 Impact factor: 53.242

6. The genetics of caloric restriction in Caenorhabditis elegans.

Authors: B Lakowski; S Hekimi
Journal: Proc Natl Acad Sci U S A Date: 1998-10-27 Impact factor: 11.205

7. The genetics of Caenorhabditis elegans.

Authors: S Brenner
Journal: Genetics Date: 1974-05 Impact factor: 4.562

Review 8. Viral evasion of T cell immunity: ancient mechanisms offering new applications.

Authors: Daniëlle Horst; Marieke C Verweij; Andrew J Davison; Maaike E Ressing; Emmanuel J H J Wiertz
Journal: Curr Opin Immunol Date: 2010-12-09 Impact factor: 7.486

9. Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses.

Authors: Marie-Anne Félix; Alyson Ashe; Joséphine Piffaretti; Guang Wu; Isabelle Nuez; Tony Bélicard; Yanfang Jiang; Guoyan Zhao; Carl J Franz; Leonard D Goldstein; Mabel Sanroman; Eric A Miska; David Wang
Journal: PLoS Biol Date: 2011-01-25 Impact factor: 8.029

10. DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.

Authors: Maria A Ermolaeva; Alexandra Segref; Alexander Dakhovnik; Hui-Ling Ou; Jennifer I Schneider; Olaf Utermöhlen; Thorsten Hoppe; Björn Schumacher
Journal: Nature Date: 2013-08-25 Impact factor: 49.962

72 in total

1. MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa.

Authors: Jessica H Hartman; Christopher T Richie; Kacy L Gordon; Danielle F Mello; Priscila Castillo; April Zhu; Yun Wang; Barry J Hoffer; David R Sherwood; Joel N Meyer; Brandon K Harvey
Journal: Eur J Cell Biol Date: 2019-05-21 Impact factor: 4.492

Review 2. Caenorhabditis elegans as a model animal for investigating fungal pathogenesis.

Authors: Moses Madende; Jacobus Albertyn; Olihile Sebolai; Carolina H Pohl
Journal: Med Microbiol Immunol Date: 2019-09-25 Impact factor: 3.402

Review 3. Antimicrobial effectors in the nematode Caenorhabditis elegans: an outgroup to the Arthropoda.

Authors: Katja Dierking; Wentao Yang; Hinrich Schulenburg
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2016-05-26 Impact factor: 6.237

4. Planarian finds time(less) to fight infection.

Authors: Óscar Gutiérrez-Gutiérrez; Daniel A Felix; Cristina González-Estévez
Journal: Virulence Date: 2017-03-02 Impact factor: 5.882

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Authors: Stefan F Martin
Journal: Cell Mol Life Sci Date: 2014-07-06 Impact factor: 9.261

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Authors: Cathy Savage-Dunn; Richard W Padgett
Journal: Cold Spring Harb Perspect Biol Date: 2017-06-01 Impact factor: 10.005

7. Role of extracellular polymeric substances in polymicrobial biofilm infections of Staphylococcus epidermidis and Candida albicans modelled in the nematode Caenorhabditis elegans.

Authors: Jillian E Holt; Asia Houston; Clare Adams; Sarah Edwards; Birthe V Kjellerup
Journal: Pathog Dis Date: 2017-07-31 Impact factor: 3.166