Ae Ryoung Kim1, Jin Woo Chang2, Won Seok Chang2, Eun Sook Park1, Sung-Rae Cho3. 1. Department of Rehabilitation Medicine and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea. 2. Department of Neurosurgery and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea. 3. Department of Rehabilitation Medicine and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea. ; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. ; Graduate School Program of Nano Science and Technology, Yonsei University, Seoul, Korea. ; Avison Biomedical Research Center, Yonsei University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE: To investigate the effect of deep brain stimulation (DBS) on reducing dystonia and disability in adults with cerebral palsy (CP) and to compare the therapeutic outcomes between primary dystonia patients and CP patients over two years after bilateral pallidal DBS. METHODS: Five patients with primary dystonia and seven CP patients with dystonia were recruited. All subjects received DBS surgery in both globus pallidus. Burke-Fahn-Marsden dystonia rating scale consisting of dystonia movement score and disability score and subjective satisfaction scale were assessed after 1 month and every 6 months over two years following DBS treatment. RESULTS: On the dystonia movement scale, both groups of primary dystonia patients and CP patients showed a significant decrease over time following DBS. On the disability scale, patients with primary dystonia showed a significant decrease over time, whereas the disability score of CP patients did not change over the two years. Comparing the dystonia movement and disability scores of CP patients at each assessment, patients with primary dystonia showed a significant reduction after 6 months. Comparing the satisfaction scores of CP patients after DBS, patients with primary dystonia showed significantly higher subjective satisfaction. CONCLUSION: Whereas dystonia can be significantly reduced in patients with primary dystonia, CP patients showed a modest improvement on the dystonia movement scale, but not on the disability scale. Therefore, DBS may be considered with caution as a treatment modality of CP patients with dystonia.
OBJECTIVE: To investigate the effect of deep brain stimulation (DBS) on reducing dystonia and disability in adults with cerebral palsy (CP) and to compare the therapeutic outcomes between primary dystoniapatients and CPpatients over two years after bilateral pallidal DBS. METHODS: Five patients with primary dystonia and seven CPpatients with dystonia were recruited. All subjects received DBS surgery in both globus pallidus. Burke-Fahn-Marsden dystonia rating scale consisting of dystonia movement score and disability score and subjective satisfaction scale were assessed after 1 month and every 6 months over two years following DBS treatment. RESULTS: On the dystonia movement scale, both groups of primary dystoniapatients and CPpatients showed a significant decrease over time following DBS. On the disability scale, patients with primary dystonia showed a significant decrease over time, whereas the disability score of CPpatients did not change over the two years. Comparing the dystonia movement and disability scores of CPpatients at each assessment, patients with primary dystonia showed a significant reduction after 6 months. Comparing the satisfaction scores of CPpatients after DBS, patients with primary dystonia showed significantly higher subjective satisfaction. CONCLUSION: Whereas dystonia can be significantly reduced in patients with primary dystonia, CPpatients showed a modest improvement on the dystonia movement scale, but not on the disability scale. Therefore, DBS may be considered with caution as a treatment modality of CPpatients with dystonia.
Entities:
Keywords:
Cerebral palsy; Deep brain stimulation; Dystonia; Dystonia rating scale
Authors: P F Katsakiori; Z Kefalopoulou; E Markaki; A Paschali; J Ellul; G C Kagadis; E Chroni; C Constantoyannis Journal: Acta Neurochir (Wien) Date: 2009-03-26 Impact factor: 2.216
Authors: Stephen Tisch; John C Rothwell; Patricia Limousin; Marwan I Hariz; Daniel M Corcos Journal: IEEE Trans Neural Syst Rehabil Eng Date: 2007-06 Impact factor: 3.802
Authors: Marta San Luciano; Amy Robichaux-Viehoever; Kristen A Dodenhoff; Melissa L Gittings; Aaron C Viser; Caroline A Racine; Ian O Bledsoe; Christa Watson Pereira; Sarah S Wang; Philip A Starr; Jill L Ostrem Journal: J Neurosurg Pediatr Date: 2020-11-27 Impact factor: 2.375
Authors: Young Kwon Yoon; Kil Chan Lee; Han Eol Cho; Minji Chae; Jin Woo Chang; Won Seok Chang; Sung-Rae Cho Journal: Medicine (Baltimore) Date: 2017-08 Impact factor: 1.889
Authors: Corina N A M van den Heuvel; Marina A J Tijssen; Bart P C van de Warrenburg; Cathérine C S Delnooz Journal: Mov Disord Clin Pract Date: 2016-08-03