Stem cell therapy for dermal wound healing.

The use of cellular therapy in the treatment of dermal wounds is currently an active area of investigation. Multipotent adult stem cells are an attractive choice for cell therapy because they have a large proliferative potential, the ability to differentiate into different cell types and produce a variety cytokines and growth factors important to wound healing. This review focused on the roles of adult stem cells such as endothelial progenitor cells, bone marrow and adipose-derived mesenchymal stem cells, during dermal wound healing process and their therapeutic potentials for the treatment of chronic wounds, which remain a major clinical problem, especially in diabetic patients.