Literature DB >> 24855528

Stem Cells Transplantation and Huntington's Disease.

Wooseok Im1, Soon-Tae Lee2, Kon Chu2, Manho Kim2, Jae-Kyu Roh2.   

Abstract

Huntington's disease (HD) is a progressive and devastating neurodegenerative disorder that results in movement abnormalities, cognitive impairments, dementia, and affective disturbances. As no proven medical therapy for this genetic disease is currently available, symptoms mitigation is the primary treatment for HD. Stem cells can play an important role in cell therapy therapeutic strategies to replace dysfunctional or dying cells in HD. Here, we present a brief overview of the current state of stem cells therapy and of the results obtained in animal models of HD, and discuss neuro-protective approaches that utilize stem cells-derived paracrine factors.

Entities:  

Keywords:  Animal model; Huntington’s disease; Stem cells

Year:  2009        PMID： 24855528      PMCID： PMC4021764          DOI： 10.15283/ijsc.2009.2.2.102

Source DB:  PubMed          Journal:  Int J Stem Cells        ISSN： 2005-3606            Impact factor:   2.500


  66 in total

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Review 2.  Human stem cell grafts as therapies for motor neuron disease.

Authors:  Vassilis E Koliatsos; Leyan Xu; Jun Yan
Journal:  Expert Opin Biol Ther       Date:  2008-02       Impact factor: 4.388

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Review 4.  Excitotoxic injury of the neostriatum: a model for Huntington's disease.

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Journal:  Trends Neurosci       Date:  1990-07       Impact factor: 13.837

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Authors:  Sebastian Jessberger; Gerd Kempermann
Journal:  Eur J Neurosci       Date:  2003-11       Impact factor: 3.386

6.  Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease.

Authors:  Jae K Ryu; Jean Kim; Sung J Cho; Kozo Hatori; Astushi Nagai; Hyun B Choi; Min C Lee; James G McLarnon; Seung U Kim
Journal:  Neurobiol Dis       Date:  2004-06       Impact factor: 5.996

7.  Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells.

Authors:  Jalees Rehman; Dmitry Traktuev; Jingling Li; Stephanie Merfeld-Clauss; Constance J Temm-Grove; Jason E Bovenkerk; Carrie L Pell; Brian H Johnstone; Robert V Considine; Keith L March
Journal:  Circulation       Date:  2004-03-01       Impact factor: 29.690

8.  Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

Authors:  Alexander V Panov; Claire-Anne Gutekunst; Blair R Leavitt; Michael R Hayden; James R Burke; Warren J Strittmatter; J Timothy Greenamyre
Journal:  Nat Neurosci       Date:  2002-08       Impact factor: 24.884

9.  Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo.

Authors:  C R Bjornson; R L Rietze; B A Reynolds; M C Magli; A L Vescovi
Journal:  Science       Date:  1999-01-22       Impact factor: 47.728

10.  Generation of purified neural precursors from embryonic stem cells by lineage selection.

Authors:  M Li; L Pevny; R Lovell-Badge; A Smith
Journal:  Curr Biol       Date:  1998-08-27       Impact factor: 10.834
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  3 in total

Review 1.  Stem Cells and Natural Agents in the Management of Neurodegenerative Diseases: A New Approach.

Authors:  Aranka Brockmueller; Negin Mahmoudi; Amir Kian Movaeni; Anna-Lena Mueller; Abdol-Mohammad Kajbafzadeh; Mehdi Shakibaei; Masoumeh Majidi Zolbin
Journal:  Neurochem Res       Date:  2022-09-16       Impact factor: 4.414

Review 2.  Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington's Disease.

Authors:  Ewelina Latoszek; Magdalena Czeredys
Journal:  Front Cell Dev Biol       Date:  2021-04-01

3.  Transplantation of human embryonic stem cells alleviates motor dysfunction in AAV2-Htt171-82Q transfected rat model of Huntington's disease.

Authors:  Jaisan Islam; Kyoung Ha So; Elina Kc; Hyeong Cheol Moon; Aryun Kim; Sang Hwan Hyun; Soochong Kim; Young Seok Park
Journal:  Stem Cell Res Ther       Date:  2021-11-22       Impact factor: 6.832
  3 in total

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