Literature DB >> 24855283

Distal convoluted tubule.

Arohan R Subramanya1, David H Ellison2.   

Abstract

The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice.
Copyright © 2014 by the American Society of Nephrology.

Entities:  

Keywords:  Na transport; distal tubule; mineral metabolism; potassium channels; renal physiology

Mesh：

Substances：

Year:  2014        PMID： 24855283      PMCID： PMC4255408          DOI： 10.2215/CJN.05920613

Source DB:  PubMed          Journal:  Clin J Am Soc Nephrol        ISSN： 1555-9041            Impact factor:   8.237


  119 in total

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4.  Increasing magnitude of electrical potential along the renal distal tubule.

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8.  WNK1 kinase isoform switch regulates renal potassium excretion.

Authors:  James B Wade; Liang Fang; Jie Liu; Dimin Li; Chao-Ling Yang; Arohan R Subramanya; Djikolngar Maouyo; Amanda Mason; David H Ellison; Paul A Welling
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-18       Impact factor: 11.205

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Review 10.  Claudins at the gate: determinants of renal epithelial tight junction paracellular permeability.

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  72 in total

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Review 2.  Pathophysiology and clinical presentations of salt-losing tubulopathies.

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4.  Clinical Pharmacology in Diuretic Use.

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6.  Regulation of renal Na transporters in response to dietary K.

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7.  Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride.

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8.  Harvest and primary culture of the murine aldosterone-sensitive distal nephron.

Authors:  Mariana Labarca; Jonathan M Nizar; Elisabeth M Walczak; Wuxing Dong; Alan C Pao; Vivek Bhalla
Journal:  Am J Physiol Renal Physiol       Date:  2015-03-25

9.  The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway.

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