Brendan Mulhern1, Clara Mukuria1, Michael Barkham1, Martin Knapp1, Sarah Byford1, Djøra Soeteman1, John Brazier1. 1. Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
Abstract
BACKGROUND: Generic preference-based measures (EuroQoL-5D (EQ-5D) and SF-6D) are used in the economic evaluation of mental health interventions. However, there are inconsistent findings regarding their psychometric properties. AIMS: To investigate the psychometric properties of the EQ-5D and SF-6D in different mental health conditions, using seven existing data-sets. METHOD: The construct validity and responsiveness of the measures were assessed in comparison with condition-specific indicators. RESULTS: Evidence for construct validity and responsiveness in common mental health and personality disorders was found (correlations 0.22-0.64; effect sizes 0.37-1.24; standardised response means 0.45-1.31). There was some evidence for validity in schizophrenia (correlations 0.05-0.43), but responsiveness was unclear. CONCLUSIONS: EQ-5D and SF-6D can be used in the economic evaluation of interventions for common mental health problems with some confidence. In schizophrenia, a preference-based measure focused on the impact of mental health should be considered. Royal College of Psychiatrists.
BACKGROUND: Generic preference-based measures (EuroQoL-5D (EQ-5D) and SF-6D) are used in the economic evaluation of mental health interventions. However, there are inconsistent findings regarding their psychometric properties. AIMS: To investigate the psychometric properties of the EQ-5D and SF-6D in different mental health conditions, using seven existing data-sets. METHOD: The construct validity and responsiveness of the measures were assessed in comparison with condition-specific indicators. RESULTS: Evidence for construct validity and responsiveness in common mental health and personality disorders was found (correlations 0.22-0.64; effect sizes 0.37-1.24; standardised response means 0.45-1.31). There was some evidence for validity in schizophrenia (correlations 0.05-0.43), but responsiveness was unclear. CONCLUSIONS: EQ-5D and SF-6D can be used in the economic evaluation of interventions for common mental health problems with some confidence. In schizophrenia, a preference-based measure focused on the impact of mental health should be considered. Royal College of Psychiatrists.
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