Huai T Ge1, Hong X Liu1, Jing Xiang2, Ai L Miao1, Lu Tang1, Qing S Guan1, Ting Wu1, Qi Q Chen3, Lu Yang3, Xiao S Wang4. 1. The Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. 2. The MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45220, USA. 3. The MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu, PR China. 4. The Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address: lidou2005@126.com.
Abstract
OBJECTIVE: The objective of this study was to investigate functional abnormalities of the brain in females with migraine using magnetoencephalography (MEG) and a finger-tapping task. METHODS:Twenty-nine female patients with migraine (aged 16-40years) and age- and gender-matched healthy controls were studied with an MEG system at a sampling rate of 6000Hz. MEG recordings were performed during an attack in migraineurs with and without aura. Neuromagnetic brain activation was elicited by a finger-tapping task. The latency and amplitude of neuromagnetic responses were analyzed with averaged waveforms in the frequency range of 5-100Hz. The Morlet wavelet and beamformers were used to analyze the spectral and spatial signatures of MEG data from subjects in two frequency ranges of 5-100 and 100-1000Hz. RESULTS: The latency of motor-evoked magnetic fields evoked by finger movement was significantly prolonged in migraineurs as compared with controls. Neuromagnetic spectral power in the motor cortex in migraineurs was significantly elevated. There were significantly higher odds of activation in 5-30, 100-300 and 500-700Hz frequency ranges in the ipsilateral primary motor cortices and the supplementary motor area in migraineurs as compared with controls. CONCLUSIONS: Neuromagnetic signal abnormalities in this study suggest cortical hyperexcitability in females with migraine during migraine attack, which could be measured and analyzed with MEG signal in a frequency range of 5-1000Hz. SIGNIFICANCE: These findings may help to identify neurophysiological biomarkers for studying mechanisms of migraine, and may facilitate to develop new therapeutic strategies for migraine by alterations in cortical excitability.
RCT Entities:
OBJECTIVE: The objective of this study was to investigate functional abnormalities of the brain in females with migraine using magnetoencephalography (MEG) and a finger-tapping task. METHODS: Twenty-nine female patients with migraine (aged 16-40years) and age- and gender-matched healthy controls were studied with an MEG system at a sampling rate of 6000Hz. MEG recordings were performed during an attack in migraineurs with and without aura. Neuromagnetic brain activation was elicited by a finger-tapping task. The latency and amplitude of neuromagnetic responses were analyzed with averaged waveforms in the frequency range of 5-100Hz. The Morlet wavelet and beamformers were used to analyze the spectral and spatial signatures of MEG data from subjects in two frequency ranges of 5-100 and 100-1000Hz. RESULTS: The latency of motor-evoked magnetic fields evoked by finger movement was significantly prolonged in migraineurs as compared with controls. Neuromagnetic spectral power in the motor cortex in migraineurs was significantly elevated. There were significantly higher odds of activation in 5-30, 100-300 and 500-700Hz frequency ranges in the ipsilateral primary motor cortices and the supplementary motor area in migraineurs as compared with controls. CONCLUSIONS: Neuromagnetic signal abnormalities in this study suggest cortical hyperexcitability in females with migraine during migraine attack, which could be measured and analyzed with MEG signal in a frequency range of 5-1000Hz. SIGNIFICANCE: These findings may help to identify neurophysiological biomarkers for studying mechanisms of migraine, and may facilitate to develop new therapeutic strategies for migraine by alterations in cortical excitability.
Authors: Kimberly A Leiken; Jing Xiang; Emily Curry; Hisako Fujiwara; Douglas F Rose; Janelle R Allen; Joanne E Kacperski; Hope L O'Brien; Marielle A Kabbouche; Scott W Powers; Andrew D Hershey Journal: J Headache Pain Date: 2016-04-26 Impact factor: 7.277