I V Reeves1, Z D Bamji2, G B Rosario1, K M Lewis3, M A Young1, K N Washington2. 1. Division of Neonatology, Department of Pediatrics and Child Health, The Howard University College of Medicine and the Howard University Hospital, Washington, DC, USA. 2. Department of Pediatrics and Child Health, Human Genetics, The Howard University College of Medicine and the Howard University Hospital, Washington, DC, USA. 3. Department of Obstetrics and Gynecology, The Howard University College of Medicine and the Howard University Hospital, Washington, DC, USA.
Abstract
OBJECTIVE: We investigated risk for comorbidities and preeclampsia at low vitamin D levels in ethnic minorities. STUDY DESIGN: Umbilical cord vitamin D (25(OH)D) concentration was determined in urban minorities: 80.9% African American and 17% Hispanic mothers-baby pairs. To identify the correlation between vitamin D levels and high-risk comorbidities which result in preeclampsia, multivariate logistic regression analyses were performed. RESULT: Below the Institute of Medicine threshold of 25(OH)D for pregnant women (25 ng ml⁻¹), obesity (P=0.055) and pregestational diabetes (odds ratio (OR)=2.056) were observed. The study median was 16 ng ml⁻¹ (<25th percentile), at which gestational hypertension (P=0.042), chronic hypertension (OR=4.842) and pregestational diabetes (OR=3.45) became relevant. The risk for preeclampsia increased 12-fold with gestational hypertension (P=0.003) and 14-fold with combined chronic and gestational hypertension (P=0.001). CONCLUSION: Pregnant women of ethnic minority had lower median vitamin D levels which may contribute to a potential risk for preeclampsia.
OBJECTIVE: We investigated risk for comorbidities and preeclampsia at low vitamin D levels in ethnic minorities. STUDY DESIGN: Umbilical cord vitamin D (25(OH)D) concentration was determined in urban minorities: 80.9% African American and 17% Hispanic mothers-baby pairs. To identify the correlation between vitamin D levels and high-risk comorbidities which result in preeclampsia, multivariate logistic regression analyses were performed. RESULT: Below the Institute of Medicine threshold of 25(OH)D for pregnant women (25 ng ml⁻¹), obesity (P=0.055) and pregestational diabetes (odds ratio (OR)=2.056) were observed. The study median was 16 ng ml⁻¹ (<25th percentile), at which gestational hypertension (P=0.042), chronic hypertension (OR=4.842) and pregestational diabetes (OR=3.45) became relevant. The risk for preeclampsia increased 12-fold with gestational hypertension (P=0.003) and 14-fold with combined chronic and gestational hypertension (P=0.001). CONCLUSION: Pregnant women of ethnic minority had lower median vitamin D levels which may contribute to a potential risk for preeclampsia.
Authors: Donna D Johnson; Carol L Wagner; Thomas C Hulsey; Rebecca B McNeil; Myla Ebeling; Bruce W Hollis Journal: Am J Perinatol Date: 2010-07-16 Impact factor: 1.862
Authors: Heather H Burris; Sheryl L Rifas-Shiman; Ken Kleinman; Augusto A Litonjua; Susanna Y Huh; Janet W Rich-Edwards; Carlos A Camargo; Matthew W Gillman Journal: Am J Obstet Gynecol Date: 2012-06-01 Impact factor: 8.661
Authors: David R McCance; Valerie A Holmes; Michael J A Maresh; Christopher C Patterson; James D Walker; Donald W M Pearson; Ian S Young Journal: Lancet Date: 2010-06-26 Impact factor: 79.321
Authors: Carlos A Camargo; Sheryl L Rifas-Shiman; Augusto A Litonjua; Janet W Rich-Edwards; Scott T Weiss; Diane R Gold; Ken Kleinman; Matthew W Gillman Journal: Am J Clin Nutr Date: 2007-03 Impact factor: 7.045