Literature DB >> 24854332

Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations.

M Hufnagel1, K Sixel, F Hammer, A Kropec, I G Sava, C Theilacker, R Berner, J Huebner.   

Abstract

Three different commercially available polyvalent immune globulins (IG) were investigated for the existence of antibodies against cell wall carbohydrates of four different E. faecalis serotypes (using a cell wall carbohydrate-enzyme-linked immunosorbent assay), and whether these antibodies mediated opsonic killing (using an opsonic-killing assay). All three IG preparations contained antibodies against all four serotypes (CPS-A to CPS-D). However, only one of the three IG preparations showed opsonic killing against all four serotypes. Average killing was higher against serotypes A and B (72 and 79 %, respectively) than against serotypes C and D (30 and 37 %, respectively). Such IG preparations could play a role as an adjuvant therapeutic option in life-threatening infections with E. faecalis, particularly when resistant strains are involved.

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Year:  2014        PMID： 24854332     DOI： 10.1007/s15010-014-0628-y

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


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