Optimization of β-cyclodextrin cross-linked polymer for monitoring of quercetin.

A novel method for the separation/analysis of quercetin was described, which was based on the investigation of the inclusion interactions of β-cyclodextrin cross-linked polymer (β-CDCP) with quercetin (Qu) and the adsorption behavior of Qu on β-CDCP. The inclusion interaction of β-CDCP with Qu was studied through FTIR, TGA and 13C NMR. Under the optimum conditions, the preconcentration factor of the proposed method was approximately 8.8, the β-CDCP could be used repeatedly for 30 times and offered better recovery. The linear range, limit of detection (LOD) and the relative standard deviation (RSD) was found to be 0.10-12.0 μg mL(-1), 4.6 ng mL(-1) and 3.10% (n=3, c=2.0 μg mL(-1)) respectively. This technique had been successfully applied to the determination of Qu in real samples.