| Literature DB >> 24854124 |
Wei Xie1, Donglin Zhu1, Li Ji1, Minjie Tian1, Chang Xu1, Jingping Shi2.
Abstract
Chronic cerebral hypoperfusion (CCH) is associated with cognitive decline in aging, vascular dementia and Alzheimer׳s disease. Recently, angiotensin-(1-7) (Ang-(1-7)), one of the physiological constituents of the brain, was found to protect against cognitive dysfunction and brain ischemia. However, the effects of Ang-(1-7) on CCH-induced cognitive deficits remained unknown. In the present study, Ang-(1-7) significantly alleviated CCH-induced cognitive deficits in rats subjected to permanent bilateral occlusion of the common carotid arteries (a model of CCH). This neuroprotective effect was associated with increased nitric oxide generation, attenuated neuronal loss and suppressed astrocyte proliferation in the hippocampus. These findings demonstrate that Ang-(1-7) is a promising therapeutic agent for CCH-induced cognitive deficits.Entities:
Keywords: Angiotensin-(1-7); Astrocyte proliferation; Chronic cerebral hypoperfusion; Hippocampus; Neuronal loss; Nitric oxide
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Year: 2014 PMID： 24854124 DOI： 10.1016/j.brainres.2014.05.019
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252