Yang Shin Park1, Chang Hee Lee2, Ji Hoon Kim3, Baek Hui Kim4, Jeoung Hyun Kim5, Kyeong Ah Kim1, Cheol Min Park1. 1. Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. 2. Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. Electronic address: chlee86@korea.ac.kr. 3. Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. 4. Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. 5. Department of Radiology, Ewha Womans University Mokdong Hospital, Seoul, Korea.
Abstract
PURPOSE: To determine whether gadolinium ethoxybenzyldiethylenetriaminepentaacetic acid (Gd-EOB-DTPA) administration affects hepatic fat quantification by magnetic resonance spectroscopy (MRS) using the fast breath-hold high-speed T2-corrected multiecho (HISTO) technique. MATERIALS AND METHODS: Seventy-six patients underwent Gd-EOB-DTPA-enhanced liver MR and 15sec breath-hold HISTO MRS (4 times), twice before and twice after Gd-EOB-DTPA administration. Two consecutive MRSs were performed immediately before the dynamic study. Post-contrast MRS was performed twice continuously, approximately 15min after contrast injection, prior to obtaining 20-min hepatobiliary phase images. We used paired t-test and intraclass correlation coefficient (ICC) to evaluate the variability of the mean fat fraction (FF) on pre-contrast MRS and post-contrast MRS and the effect of the contrast agent on the mean FF. RESULTS: The mean FFs were not significantly different between pre-contrast MRS and post-contrast MRS (6.50%±6.54 versus 6.70%±6.61, P=0.15). The ICC of FF calculation between pre- and post-contrast MRS was 0.984. The ICCs for the FF magnitude between pre- and post-contrast MRS were 0.452, 0.771, and 0.995 for FF <5%, FF 5-10%, and FF ≥10%, respectively. CONCLUSION: Gd-EOB-DTPA does not appear to influence hepatic fat quantification, especially for patients with hepatic steatosis.
PURPOSE: To determine whether gadolinium ethoxybenzyldiethylenetriaminepentaacetic acid (Gd-EOB-DTPA) administration affects hepatic fat quantification by magnetic resonance spectroscopy (MRS) using the fast breath-hold high-speed T2-corrected multiecho (HISTO) technique. MATERIALS AND METHODS: Seventy-six patients underwent Gd-EOB-DTPA-enhanced liver MR and 15sec breath-hold HISTO MRS (4 times), twice before and twice after Gd-EOB-DTPA administration. Two consecutive MRSs were performed immediately before the dynamic study. Post-contrast MRS was performed twice continuously, approximately 15min after contrast injection, prior to obtaining 20-min hepatobiliary phase images. We used paired t-test and intraclass correlation coefficient (ICC) to evaluate the variability of the mean fat fraction (FF) on pre-contrast MRS and post-contrast MRS and the effect of the contrast agent on the mean FF. RESULTS: The mean FFs were not significantly different between pre-contrast MRS and post-contrast MRS (6.50%±6.54 versus 6.70%±6.61, P=0.15). The ICC of FF calculation between pre- and post-contrast MRS was 0.984. The ICCs for the FF magnitude between pre- and post-contrast MRS were 0.452, 0.771, and 0.995 for FF <5%, FF 5-10%, and FF ≥10%, respectively. CONCLUSION:Gd-EOB-DTPA does not appear to influence hepatic fat quantification, especially for patients with hepatic steatosis.