OBJECTIVE: To assess the risk for preeclampsia (PE) by maternal characteristics, serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) at 30-33 weeks' gestation. METHODS: This was a screening study in singleton pregnancies including 2,140 that subsequently developed PE and 83,615 that were unaffected by PE, gestational hypertension or delivery of small-for-gestational-age neonates (normal group). We developed a survival time model for the time of delivery for PE by combination of maternal characteristics and history with PlGF and sFlt-1 multiple of the median (MoM) values (biochemical test). Data on third-trimester PlGF and sFlt-1 were available in 118 cases of PE and 3,734 of normal group. The detection rate (DR) of PE requiring delivery within 4, 6 and 8 weeks of the visit was estimated. RESULTS: In pregnancies with PE, the log10 MoM values of PlGF and sFlt-1 were linearly related to gestational age at delivery. Screening by the biochemical test detected 100, 76, and 62% of PE with delivery within 4, 6 and 8 weeks of the visit, at a fixed false-positive rate of 5%. INTERPRETATION: Testing by PlGF and sFlt-1 at 30-33 weeks could identify all pregnancies developing PE and requiring delivery within the subsequent 4 weeks.
OBJECTIVE: To assess the risk for preeclampsia (PE) by maternal characteristics, serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) at 30-33 weeks' gestation. METHODS: This was a screening study in singleton pregnancies including 2,140 that subsequently developed PE and 83,615 that were unaffected by PE, gestational hypertension or delivery of small-for-gestational-age neonates (normal group). We developed a survival time model for the time of delivery for PE by combination of maternal characteristics and history with PlGF and sFlt-1 multiple of the median (MoM) values (biochemical test). Data on third-trimester PlGF and sFlt-1 were available in 118 cases of PE and 3,734 of normal group. The detection rate (DR) of PE requiring delivery within 4, 6 and 8 weeks of the visit was estimated. RESULTS: In pregnancies with PE, the log10 MoM values of PlGF and sFlt-1 were linearly related to gestational age at delivery. Screening by the biochemical test detected 100, 76, and 62% of PE with delivery within 4, 6 and 8 weeks of the visit, at a fixed false-positive rate of 5%. INTERPRETATION: Testing by PlGF and sFlt-1 at 30-33 weeks could identify all pregnancies developing PE and requiring delivery within the subsequent 4 weeks.
Authors: Glenn E Palomaki; James E Haddow; Hamish R M Haddow; Saira Salahuddin; Carl Geahchan; Ana Sofia Cerdeira; Stefan Verlohren; Frank H Perschel; Gary Horowitz; Ravi Thadhani; S Ananth Karumanchi; Sarosh Rana Journal: Prenat Diagn Date: 2015-02-04 Impact factor: 3.050
Authors: H Stepan; I Herraiz; D Schlembach; S Verlohren; S Brennecke; F Chantraine; E Klein; O Lapaire; E Llurba; A Ramoni; M Vatish; D Wertaschnigg; A Galindo Journal: Ultrasound Obstet Gynecol Date: 2015-03 Impact factor: 7.299
Authors: Kym I E Snell; John Allotey; Melanie Smuk; Richard Hooper; Claire Chan; Asif Ahmed; Lucy C Chappell; Peter Von Dadelszen; Marcus Green; Louise Kenny; Asma Khalil; Khalid S Khan; Ben W Mol; Jenny Myers; Lucilla Poston; Basky Thilaganathan; Anne C Staff; Gordon C S Smith; Wessel Ganzevoort; Hannele Laivuori; Anthony O Odibo; Javier Arenas Ramírez; John Kingdom; George Daskalakis; Diane Farrar; Ahmet A Baschat; Paul T Seed; Federico Prefumo; Fabricio da Silva Costa; Henk Groen; Francois Audibert; Jacques Masse; Ragnhild B Skråstad; Kjell Å Salvesen; Camilla Haavaldsen; Chie Nagata; Alice R Rumbold; Seppo Heinonen; Lisa M Askie; Luc J M Smits; Christina A Vinter; Per Magnus; Kajantie Eero; Pia M Villa; Anne K Jenum; Louise B Andersen; Jane E Norman; Akihide Ohkuchi; Anne Eskild; Sohinee Bhattacharya; Fionnuala M McAuliffe; Alberto Galindo; Ignacio Herraiz; Lionel Carbillon; Kerstin Klipstein-Grobusch; Seon Ae Yeo; Joyce L Browne; Karel G M Moons; Richard D Riley; Shakila Thangaratinam Journal: BMC Med Date: 2020-11-02 Impact factor: 8.775
Authors: Ignacio Herraiz; Elisa Simón; Paula Isabel Gómez-Arriaga; José Manuel Martínez-Moratalla; Antonio García-Burguillo; Elena Ana López Jiménez; Alberto Galindo Journal: Int J Mol Sci Date: 2015-08-13 Impact factor: 5.923
Authors: H Stepan; M Hund; M Gencay; B Denk; C Dinkel; W E Kaminski; P Wieloch; B Semus; T Meloth; L-A Dröge; S Verlohren Journal: Hypertens Pregnancy Date: 2016-03-30 Impact factor: 2.108