| Literature DB >> 24852445 |
Olesya I Zhuravleva1, Maria P Sobolevskaya, Elena V Leshchenko, Natalya N Kirichuk, Vladimir A Denisenko, Pavel S Dmitrenok, Sergey A Dyshlovoy, Alexander M Zakharenko, Natalya Yu Kim, Shamil Sh Afiyatullov.
Abstract
Ten new austalide meroterpenoids (1-10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher's method and CD data. Compounds 1, 2, 8, and 9 were able to inhibit AP-1-dependent transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations. Austalides 1-5, 8, and 9 exhibited significant inhibitory activity against endo-1,3-β-D-glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis.Entities:
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Year: 2014 PMID： 24852445 DOI： 10.1021/np500151b
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050