Juan Meng1, Yuewu Lu2, Xin Dong1, Hongyan Liu1. 1. Department of Rheumatology & Immunology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. 2. Department of Rheumatology & Immunology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Email: llyyww615@sina.com.
Abstract
OBJECTIVE: To observe the long-term effects of hydroxychloroquine treatment on blood lipids and left ventricular function of systemic lupus erythematosus (SLE) patients. METHODS: A total of 72 SLE patients were randomly divided into 2 groups of hydroxychloroquine treatment (n = 36) and non-hydroxychloroquine (n = 36). The serum level of lipids, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), fractional shortening rate (FS), left ventricular ejection fraction (LVEF) and E/A ratio were measured before, 6 month, 12 month and 2 years after treatment. RESULTS: After long-term use of hydroxychloroquine, there were statistically differences in the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). And LVEDD, LVWPT and E/A were statistically different (P < 0.05) before and after hydroxychloroquine dosing. CONCLUSION: The long-term use of hydroxychloroquine may improve lipid metabolism and left ventricular function in SLE patients.
RCT Entities:
OBJECTIVE: To observe the long-term effects of hydroxychloroquine treatment on blood lipids and left ventricular function of systemic lupus erythematosus (SLE) patients. METHODS: A total of 72 SLEpatients were randomly divided into 2 groups of hydroxychloroquine treatment (n = 36) and non-hydroxychloroquine (n = 36). The serum level of lipids, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), fractional shortening rate (FS), left ventricular ejection fraction (LVEF) and E/A ratio were measured before, 6 month, 12 month and 2 years after treatment. RESULTS: After long-term use of hydroxychloroquine, there were statistically differences in the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). And LVEDD, LVWPT and E/A were statistically different (P < 0.05) before and after hydroxychloroquine dosing. CONCLUSION: The long-term use of hydroxychloroquine may improve lipid metabolism and left ventricular function in SLEpatients.
Authors: Jose Felix Restrepo; Inmaculada Del Rincon; Emily Molina; Daniel F Battafarano; Agustin Escalante Journal: J Clin Rheumatol Date: 2017-04 Impact factor: 3.517