Intravenous injection of caerulein or cholecystokinin increases the parotid-type and pancreatic-type amylase in the serum of rats.

Caerulein and cholecystokinin (CCK) injection (i.v.) into rats caused about a 2.3- and 1.9-fold increase in serum amylase activity within 2 h, respectively. The increase of amylase activity in the serum caused by pilocarpine or isoproterenol injection (i.p.) was only of parotid-type amylase. Caerulein or CCK markedly increased pancreatic-type amylase, and significantly increased parotid-type amylase in the serum.