Erli Pei1, Jue Li2, Chenhui Lu3, Jichong Xu3, Tao Tang3, Meng Ye3, Xiaoping Zhang4, Maoquan Li5. 1. Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China; Institute of Medical Intervention Engineering, Tongji University, North Zhongshan Road, Shanghai, China. 2. Heart, Lung and Blood Vessel Center, Tongji University School of Medicine, Siping Road, Shanghai, China. 3. Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China. 4. Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China; Heart, Lung and Blood Vessel Center, Tongji University School of Medicine, Siping Road, Shanghai, China. Electronic address: zxpkxy@126.com. 5. Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Shanghai, China; Heart, Lung and Blood Vessel Center, Tongji University School of Medicine, Siping Road, Shanghai, China. Electronic address: cjr.limaoquan@163.vip.com.
Abstract
BACKGROUND: To conduct a meta-analysis of case-control studies to determine the effects of lipids and lipoproteins on morbidity of diabetic foot in adults with type 2 diabetes. METHODS: We searched the PubMed and EMBASE to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to determine the quality of selected studies. We assessed the strength of associations using standardized mean differences with 95% confidence intervals. RESULTS: A total of 4 articles were found. Decreased HDL-cholesterol had a significant association with diabetic foot susceptibility in fixed-effects model, but no significant associations were found between diabetic foot and LDL-cholesterol, TC or TG levels. CONCLUSIONS: Our results suggested that decreased HDL-cholesterol was associated with diabetic foot, so possible measures to prevent diabetic foot should include targeting increases in HDL-cholesterol.
BACKGROUND: To conduct a meta-analysis of case-control studies to determine the effects of lipids and lipoproteins on morbidity of diabetic foot in adults with type 2 diabetes. METHODS: We searched the PubMed and EMBASE to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to determine the quality of selected studies. We assessed the strength of associations using standardized mean differences with 95% confidence intervals. RESULTS: A total of 4 articles were found. Decreased HDL-cholesterol had a significant association with diabetic foot susceptibility in fixed-effects model, but no significant associations were found between diabetic foot and LDL-cholesterol, TC or TG levels. CONCLUSIONS: Our results suggested that decreased HDL-cholesterol was associated with diabetic foot, so possible measures to prevent diabetic foot should include targeting increases in HDL-cholesterol.
Authors: Juan R Ulloque-Badaracco; Melany D Mosquera-Rojas; Enrique A Hernandez-Bustamante; Esteban A Alarcón-Braga; Ricardo R Ulloque-Badaracco; Ali Al-Kassab-Córdova; Percy Herrera-Añazco; Vicente A Benites-Zapata; Adrian V Hernandez Journal: Int J Clin Pract Date: 2022-08-10 Impact factor: 3.149