Literature DB >> 24849641

Clozapine induced tubulointerstitial nephritis in a patient with paranoid schizophrenia.

Ravi Parekh1, Zozik Fattah2, Dilraj Sahota3, Bernie Colaco4.   

Abstract

We describe the development of tubulointerstitial nephritis after starting clozapine therapy in a patient with treatment-resistant schizophrenia. A 54-year-old mixed-race patient with a longstanding history of paranoid schizophrenia was started on the antipsychotic clozapine. Two months after starting clozapine he developed fevers, cough and acute renal failure which initially responded to 7 days of prednisolone but recurred after completing the steroid course. Renal biopsy confirmed acute tubulointerstitial nephritis and he was started on a course of steroids with renal recovery in 72 h. Clozapine was later stopped. This case highlights a serious and potential life-threatening complication of an important antipsychotic used in treatment-resistant schizophrenia. 2014 BMJ Publishing Group Ltd.

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Year:  2014        PMID： 24849641      PMCID： PMC4039933          DOI： 10.1136/bcr-2013-203502

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  10 in total

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Journal:  Kidney Int       Date:  2001-08       Impact factor: 10.612

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Journal:  Nefrologia       Date:  2002       Impact factor: 2.033

5.  Clozapine-induced acute interstitial nephritis.

Authors:  Alexander F Au; Vinay Luthra; Robert Stern
Journal:  Am J Psychiatry       Date:  2004-08       Impact factor: 18.112

6.  Anti-PCNA antibodies: prevalence and predictive value.

Authors:  Odile Beyne-Rauzy; Sophie Thébault; Daniel Adoue; Françoise Fortenfant
Journal:  Joint Bone Spine       Date:  2005-03-22       Impact factor: 4.929

7.  Antinuclear antibodies directed against proliferating cell nuclear antigen are not specifically associated with systemic lupus erythematosus.

Authors:  P Vermeersch; K Op De Beeck; B R Lauwerys; K Van den Bergh; M Develter; G Mariën; F A Houssiau; X Bossuyt
Journal:  Ann Rheum Dis       Date:  2009-11       Impact factor: 19.103

8.  A case of acute renal failure in a patient recently treated with clozapine and a review of previously reported cases.

Authors:  J Daniel Kanofsky; Mary E Woesner; Alexander Z Harris; James P Kelleher; Karen Gittens; Elina Jerschow
Journal:  Prim Care Companion CNS Disord       Date:  2011

9.  Clozapine-induced acute interstitial nephritis.

Authors:  T J Elias; K M Bannister; A R Clarkson; D Faull; R J Faull
Journal:  Lancet       Date:  1999-10-02       Impact factor: 79.321

10.  Clozapine-induced interstitial nephritis - a rare but important complication: a case report.

Authors:  Robert Hunter; Tracey Gaughan; Filippo Queirazza; Dina McMillan; Susan Shankie
Journal:  J Med Case Rep       Date:  2009-08-27
  10 in total
  2 in total

1.  A Retrospective Cohort Study of Acute Kidney Injury Risk Associated with Antipsychotics.

Authors:  Yawen Jiang; Jeffrey S McCombs; Susie H Park
Journal:  CNS Drugs       Date:  2017-04       Impact factor: 5.749

2.  Acute Interstitial Nephritis Induced by Clozapine.

Authors:  Praveena Vantipalli; Sasmit Roy; Narayana M Koduri; Venu Madhav Konala; Amarinder Singh Garcha; Srikanth Kunaparaju; Raul Ayala; Samanvitha Sai Yarram; Sreedhar Adapa
Journal:  J Med Cases       Date:  2022-06-16
  2 in total

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