PURPOSE OF REVIEW: Possible mechanisms in cellular senescence and the senescence-associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered. RECENT FINDINGS: A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging. SUMMARY: Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.
PURPOSE OF REVIEW: Possible mechanisms in cellular senescence and the senescence-associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered. RECENT FINDINGS: A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging. SUMMARY: Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.
Authors: Pavan Parikh; Rodney D Britt; Logan J Manlove; Sarah A Wicher; Anne Roesler; Jovanka Ravix; Jacob Teske; Michael A Thompson; Gary C Sieck; James L Kirkland; Nathan LeBrasseur; Daniel J Tschumperlin; Christina M Pabelick; Y S Prakash Journal: Am J Respir Cell Mol Biol Date: 2019-07 Impact factor: 6.914
Authors: Breno Satler Diniz; Charles F Reynolds; Etienne Sibille; Chien-Wei Lin; George Tseng; Francis Lotrich; Howard J Aizenstein; Meryl A Butters Journal: Am J Geriatr Psychiatry Date: 2016-08-31 Impact factor: 4.105
Authors: James L Kirkland; Tamara Tchkonia; Yi Zhu; Laura J Niedernhofer; Paul D Robbins Journal: J Am Geriatr Soc Date: 2017-09-04 Impact factor: 5.562