BACKGROUND: Individuals with a family history of alcoholism (FH+) are at enhanced risk of developing alcohol or other substance use disorders relative to those with no family history (FH-). Alcoholics and FH+ subjects have greater interference scores on the Stroop color-word task, suggesting these impairments may be a component of the cognitive phenotype of at-risk individuals. METHODS: In this study, we examined whole-brain activations in 24 FH+ and 28 FH- young adults performing the counting Stroop task, a variant of the Stroop task adapted for neuroimaging studies. RESULTS: Across all subjects, incongruent versus congruent comparisons showed activations in regions including parietal lobe areas, frontal eye fields, premotor areas, the anterior cingulate cortex, dorsolateral prefrontal cortex, and bilateral insula, indicating typical regions of activation involved in conflict resolution tasks. Compared with FH- participants, FH+ participants had greater activations in the left superior parietal lobule and precuneus (BA 7 and 19), inferior parietal lobule (BA 40), and middle temporal gyrus (BA 39 and 19), indicating a predominance of greater left hemisphere activity among FH+ in temporoparietal regions. There were no regions showing greater activations in the FH- group compared with the FH+ group. CONCLUSIONS: These results are consistent with less efficient cognitive functioning potentially due to poorer communication over long pathways connecting temporoparietal regions to prefrontal brain regions that participate in a distributed network involved in cognitive processing and working memory necessary for conflict resolution.
BACKGROUND: Individuals with a family history of alcoholism (FH+) are at enhanced risk of developing alcohol or other substance use disorders relative to those with no family history (FH-). Alcoholics and FH+ subjects have greater interference scores on the Stroop color-word task, suggesting these impairments may be a component of the cognitive phenotype of at-risk individuals. METHODS: In this study, we examined whole-brain activations in 24 FH+ and 28 FH- young adults performing the counting Stroop task, a variant of the Stroop task adapted for neuroimaging studies. RESULTS: Across all subjects, incongruent versus congruent comparisons showed activations in regions including parietal lobe areas, frontal eye fields, premotor areas, the anterior cingulate cortex, dorsolateral prefrontal cortex, and bilateral insula, indicating typical regions of activation involved in conflict resolution tasks. Compared with FH- participants, FH+ participants had greater activations in the left superior parietal lobule and precuneus (BA 7 and 19), inferior parietal lobule (BA 40), and middle temporal gyrus (BA 39 and 19), indicating a predominance of greater left hemisphere activity among FH+ in temporoparietal regions. There were no regions showing greater activations in the FH- group compared with the FH+ group. CONCLUSIONS: These results are consistent with less efficient cognitive functioning potentially due to poorer communication over long pathways connecting temporoparietal regions to prefrontal brain regions that participate in a distributed network involved in cognitive processing and working memory necessary for conflict resolution.
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: T Reich; H J Edenberg; A Goate; J T Williams; J P Rice; P Van Eerdewegh; T Foroud; V Hesselbrock; M A Schuckit; K Bucholz; B Porjesz; T K Li; P M Conneally; J I Nurnberger; J A Tischfield; R R Crowe; C R Cloninger; W Wu; S Shears; K Carr; C Crose; C Willig; H Begleiter Journal: Am J Med Genet Date: 1998-05-08
Authors: Claire E Wilcox; Joshua Clifford; Josef Ling; Andrew R Mayer; Rose Bigelow; Michael P Bogenschutz; J Scott Tonigan Journal: Brain Imaging Behav Date: 2020-04 Impact factor: 3.978
Authors: William R Lovallo; Mary-Anne Enoch; Ashley Acheson; Andrew J Cohoon; Kristen H Sorocco; Colin A Hodgkinson; Andrea S Vincent; David Goldman Journal: Neuropsychopharmacology Date: 2015-12-03 Impact factor: 7.853
Authors: William R Lovallo; Ashley Acheson; Andrew J Cohoon; Kristen H Sorocco; Andrea S Vincent; Colin A Hodgkinson; David Goldman Journal: PLoS One Date: 2019-06-11 Impact factor: 3.240