Literature DB >> 24848084

Asymptomatic Clostridium difficile colonization as a reservoir for Clostridium difficile infection.

Alison L Galdys1, Scott R Curry, Lee H Harrison.   

Abstract

Clostridium difficile (CD) infection (CDI) is the leading cause of healthcare associated diarrhea despite intense hospital infection prevention programs. A substantial proportion of the population is asymptomatically colonized with CD, and evidence is mounting that these individuals serve as a reservoir for CDI. The purpose of this review is to discuss the mechanisms by which individuals may harbor toxigenic CD but remain asymptomatic, the evidence that asymptomatically colonized individuals serve as a source of CDI, and the implications of this potential CD reservoir for healthcare infection prevention.

Entities:  

Keywords:  Clostridium difficile; Clostridium difficile infection; asymptomatic carriage; colonization; epidemiology; molecular epidemiology

Mesh：

Year:  2014        PMID： 24848084     DOI： 10.1586/14787210.2014.920252

Source DB:  PubMed          Journal:  Expert Rev Anti Infect Ther        ISSN： 1478-7210            Impact factor:   5.091


  16 in total

Review 1.  Immune-based treatment and prevention of Clostridium difficile infection.

Authors:  Song Zhao; Chandrabali Ghose-Paul; Keshan Zhang; Saul Tzipori; Xingmin Sun
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

2.  Cirrhosis and C. difficile: A Deadly Duo?

Authors:  Stephen M Vindigni; Christina M Surawicz
Journal:  Dig Dis Sci       Date:  2015-10       Impact factor: 3.199

Review 3.  Colonization with toxinogenic C. difficile upon hospital admission, and risk of infection: a systematic review and meta-analysis.

Authors:  Ioannis M Zacharioudakis; Fainareti N Zervou; Elina Eleftheria Pliakos; Panayiotis D Ziakas; Eleftherios Mylonakis
Journal:  Am J Gastroenterol       Date:  2015-03-03       Impact factor: 10.864

Review 4.  Clostridium Difficile Infection from a Surgical Perspective.

Authors:  Andreas M Kaiser; Rachel Hogen; Liliana Bordeianou; Karim Alavi; Paul E Wise; Ranjan Sudan
Journal:  J Gastrointest Surg       Date:  2015-04-28       Impact factor: 3.452

Review 5.  Understanding Clostridium difficile Colonization.

Authors:  Monique J T Crobach; Jonathan J Vernon; Vivian G Loo; Ling Yuan Kong; Séverine Péchiné; Mark H Wilcox; Ed J Kuijper
Journal:  Clin Microbiol Rev       Date:  2018-03-14       Impact factor: 26.132

6.  Asymptomatic carriers of toxigenic C. difficile in long-term care facilities: a meta-analysis of prevalence and risk factors.

Authors:  Panayiotis D Ziakas; Ioannis M Zacharioudakis; Fainareti N Zervou; Christos Grigoras; Elina Eleftheria Pliakos; Eleftherios Mylonakis
Journal:  PLoS One       Date:  2015-02-23       Impact factor: 3.240

7.  Clostridium difficile colonization in preoperative colorectal cancer patients.

Authors:  Yi Zheng; Yun Luo; Yinxiang Lv; Chen Huang; Qinsong Sheng; Peng Zhao; Julian Ye; Weiqin Jiang; Lulu Liu; Xiaojun Song; Zhou Tong; Wenbin Chen; Jianjiang Lin; Yi-Wei Tang; Dazhi Jin; Weijia Fang
Journal:  Oncotarget       Date:  2017-02-14

8.  Isolation of C. difficile Carriers Alone and as Part of a Bundle Approach for the Prevention of Clostridium difficile Infection (CDI): A Mathematical Model Based on Clinical Study Data.

Authors:  Christos A Grigoras; Fainareti N Zervou; Ioannis M Zacharioudakis; Constantinos I Siettos; Eleftherios Mylonakis
Journal:  PLoS One       Date:  2016-06-03       Impact factor: 3.240

9.  Colonization of toxigenic Clostridium difficile among ICU patients: a prospective study.

Authors:  Xiaoxia Zhang; Xiaohui Wang; Jingyu Yang; Xiaohua Liu; Lin Cai; Zhiyong Zong
Journal:  BMC Infect Dis       Date:  2016-08-09       Impact factor: 3.090

10.  The zoonotic potential of Clostridium difficile from small companion animals and their owners.

Authors:  Denise Rabold; Werner Espelage; Muna Abu Sin; Tim Eckmanns; Alexander Schneeberg; Heinrich Neubauer; Nadine Möbius; Katja Hille; Lothar H Wieler; Christian Seyboldt; Antina Lübke-Becker
Journal:  PLoS One       Date:  2018-02-23       Impact factor: 3.240
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