Gwang Suk Kim1, Yoonsuk Jekal2, Hee Soon Kim3, Jee-Aee Im4, Ji Young Park5, Sang Hui Chu6. 1. Department of Nursing Environments and Systems, Yonsei University College of Nursing, Nursing Policy Research Institute, Republic of Korea. 2. Faculty of Exercise and Sports Sciences, College of Natural Science, Jeju National University, Republic of Korea. 3. Department of Family Health Care, Yonsei University College of Nursing, Nursing Policy Research Institute, Biobehavioral Research Center, Republic of Korea. 4. Sport and Medicine Research Center, INTOTO, Inc., Seoul, Republic of Korea. 5. Yonsei University College of Nursing, Republic of Korea. 6. Department of Clinical Nursing Science, Yonsei University College of Nursing, Nursing Policy Research Institute, Biobehavioral Research Center, Republic of Korea. Electronic address:shchu@yuhs.ac.
Abstract
BACKGROUND: Recently, osteocalcin (OC), an osteoblast-derived hormone, has been suggested as a new link between obesity and insulin resistance in humans. However, few studies regarding the relationship between OC and obesity in Asian children have been published. We investigated the association of OC with adiposity, insulin resistance and metabolic syndrome (MetS) in Korean children. METHODS: Two hundred and nine (100 boys, 109 girls) children (age: 9.78 ± 1.05 years, body mass index (BMI): 22.27 ± 5.34 kg/m(2)) participated in this cross-sectional study. Anthropometric parameters, insulin resistance, lipid profiles, total OC, and an inflammatory marker, C-reactive protein (CRP), were measured. MetS phenotype was also determined. RESULTS: Serum total OC levels were significantly lower in overweight or obese children (76.96 ± 27.08 ng/ml vs. 66.91 ± 21.39 ng/ml, p = 0.020) and it was negatively associated with body fat after controlling for age, gender and BMI. Serum total OC concentrations were significantly lower in participants with central obesity or at least two components of MetS driven by waist circumference than they were in those with none. Stepwise linear regression results also showed that serum total OC was partially explained by age, gender, waist-to-hip ratio, and fasting glucose. CONCLUSIONS: This study supported a negative association between serum total OC and adiposity in children. OC may be associated with childhood central obesity; however, further research using more accurate measurements is needed to identify the association between these variables.
BACKGROUND: Recently, osteocalcin (OC), an osteoblast-derived hormone, has been suggested as a new link between obesity and insulin resistance in humans. However, few studies regarding the relationship between OC and obesity in Asian children have been published. We investigated the association of OC with adiposity, insulin resistance and metabolic syndrome (MetS) in Korean children. METHODS: Two hundred and nine (100 boys, 109 girls) children (age: 9.78 ± 1.05 years, body mass index (BMI): 22.27 ± 5.34 kg/m(2)) participated in this cross-sectional study. Anthropometric parameters, insulin resistance, lipid profiles, total OC, and an inflammatory marker, C-reactive protein (CRP), were measured. MetS phenotype was also determined. RESULTS: Serum total OC levels were significantly lower in overweight or obesechildren (76.96 ± 27.08 ng/ml vs. 66.91 ± 21.39 ng/ml, p = 0.020) and it was negatively associated with body fat after controlling for age, gender and BMI. Serum total OC concentrations were significantly lower in participants with central obesity or at least two components of MetS driven by waist circumference than they were in those with none. Stepwise linear regression results also showed that serum total OC was partially explained by age, gender, waist-to-hip ratio, and fasting glucose. CONCLUSIONS: This study supported a negative association between serum total OC and adiposity in children. OC may be associated with childhood central obesity; however, further research using more accurate measurements is needed to identify the association between these variables.
Authors: L N Mosca; T B L Goldberg; V N da Silva; C S Kurokawa; A C B Rizzo; C C da Silva; A Dos Santos Teixeira; J E Corrente Journal: Osteoporos Int Date: 2016-11-30 Impact factor: 4.507
Authors: Krzysztof Jeziorny; Ewa Zmyslowska-Polakowska; Krystyna Wyka; Aleksandra Pyziak-Skupień; Maciej Borowiec; Agnieszka Szadkowska; Agnieszka Zmysłowska Journal: Bone Rep Date: 2022-07-01