Literature DB >> 2484757

Induction of hepatic metallothionein by salicylate in adult rats.

T Günther1, J Vormann, J Ghaida.   

Abstract

Application of salicylate increased the concentration of metallothionein (MT) in liver of pregnant rats as well as of adult male rats, whereas in fetal liver, MT was reduced by salicylate. Induction of MT synthesis by salicylate is an indirect effect because in cultured hepatocytes salicylate did not induce MT synthesis. Salicylate increased MT also in adrenalectomized rats. Indomethacin induced the same concentration of MT in maternal liver as salicylate. However, indomethacin had no effect on MT in fetal liver. Induction of MT in adult liver by salicylate and indomethacin was independent of zinc.

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Year:  1989        PMID： 2484757     DOI： 10.1007/bf02917439

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  25 in total

1.  Prostaglandin-synthesizing system in rat liver.

Authors:  I Morita; S I Murota
Journal:  Eur J Biochem       Date:  1978-10-16

2.  Inhibition of prostaglandin synthesis in man.

Authors:  M Hamberg
Journal:  Biochem Biophys Res Commun       Date:  1972-11-01       Impact factor: 3.575

3.  Altered zinc homeostasis and hepatic accumulation of metallothionein in indomethacin-induced enteropathy.

Authors:  P Z Sobocinski; G L Knutsen; W J Canterbury; E C Hauer
Journal:  Toxicol Appl Pharmacol       Date:  1979-09-30       Impact factor: 4.219

4.  Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues.

Authors:  D L Eaton; B F Toal
Journal:  Toxicol Appl Pharmacol       Date:  1982-10       Impact factor: 4.219

5.  Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

Authors:  D M Durnam; J S Hoffman; C J Quaife; E P Benditt; H Y Chen; R L Brinster; R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

6.  Acetylation of the NH2-terminal serine of prostaglandin synthetase by aspirin.

Authors:  G J Roth; C J Siok
Journal:  J Biol Chem       Date:  1978-06-10       Impact factor: 5.157

7.  Variation in the amounts of hepatic copper, zinc and metallothionein mRNA during development in the rat.

Authors:  J F Mercer; A Grimes
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857

8.  Metallothionein synthesis in foetal, neonatal and maternal rat liver.

Authors:  J E Piletz; R D Andersen; B W Birren; H R Herschman
Journal:  Eur J Biochem       Date:  1983-04-05

9.  The influence of zinc on the ontogeny of hepatic metallothionein in the fetal rat.

Authors:  V L Charles-Shannon; L B Sasser; D K Burbank; B J Kelman
Journal:  Proc Soc Exp Biol Med       Date:  1981-10

10.  Zinc deficiency in pregnant Long-Evans hooded rats: teratogenicity and tissue trace elements.

Authors:  J M Rogers; C L Keen; L S Hurley
Journal:  Teratology       Date:  1985-02
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  1 in total

1.  Protection against salicylate-induced hepatic injury by zinc. A histochemical and biochemical study.

Authors:  T Günther; R Gossrau; J Vormann; M Ruhnke
Journal:  Histochem J       Date:  1991-02
  1 in total

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