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Literature DB >> 2484564

The metabolism of metals in rat placenta.

Abstract

The status and transfer of metals across the rat placenta were studied by subcellular and molecular fractionations of this organ at 2 and 24 h after iv injection of radiolabeled metals. The soluble and nuclear fractions showed higher contents of copper and zinc, whereas most of the nickel was associated with the soluble fraction. Cadmium was almost evenly distributed between the microsomal and nuclear fractions. Gel filtration of the soluble fractions showed nickel associated with an unknown low molecular weight form; zinc with high molecular weight proteins; copper with metallothionein, ceruloplasmin, and high molecular weight proteins; and cadmium with high molecular weight proteins and metallothionein.

Entities: Chemical Gene Species

Mesh：

Substances：
Metals

Year: 1988 PMID： 2484564 DOI： 10.1007/bf02917503

Source DB: PubMed Journal: Biol Trace Elem Res ISSN： 0163-4984 Impact factor: 3.738

11 in total

1. Characterization and cellular distribution of acidic peptide and oligosaccharide metal-binding compounds from kidneys.

Authors: P F Predki; D M Whitfield; B Sarkar
Journal: Biochem J Date: 1992-02-01 Impact factor: 3.857

2. Metal-protein interactions in transport, accumulation, and excretion of metals.

Authors: B Sarkar
Journal: Biol Trace Elem Res Date: 1989 Jul-Sep Impact factor: 3.738

2 in total

The metabolism of metals in rat placenta.

1. Absorption, deposition and placental transfer of zinc65 in the rat.

2. A rapid colorimetric method for the quantitative determination of copper oxidase activity (ceruloplasmin).

3. Zinc turnover in mice during pregnancy, lactation, and growth.

4. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.

5. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

6. Induction of metallothionein in a human trophoblast cell line by cadmium and zinc.

7. Nickel-sequestering renal glycoprotein.

8. Placental transport and embryonic utilization of essential metabolites in the rat at the teratogenic dose of cadmium.

9. The acute toxicity and teratogenicity of nickel in pregnant rats.

10. Copper metabolism in pregnant and pospartum rat and pups.

1. Characterization and cellular distribution of acidic peptide and oligosaccharide metal-binding compounds from kidneys.

2. Metal-protein interactions in transport, accumulation, and excretion of metals.