Roy Alon1, Ehud I Assia1, Guy Kleinmann2. 1. Department of Ophthalmology, Meir Medical Center, Kfar-Saba, Israel. 2. Department of Ophthalmology, Kaplan Medical Center, Rehovot, Israel.
Abstract
PURPOSE: To investigate the ability of an open capsule device to prevent posterior capsule opacification. METHODS: A total of 40 eyes of 20 New Zealand white rabbits were randomly divided into six similar groups of 6 to 7 eyes each. After crystalline lens evacuation, one control group (group A) was implanted with a hydrophilic acrylic intraocular lens and no device, and another control group (group B) was implanted with a hydrophobic acrylic intraocular lens and no device. The study groups were implanted with a hydrophilic acrylic intraocular lens and a hydrophilic acrylic device (group C), a hydrophobic acrylic intraocular lens and a hydrophilic acrylic device (group D), a hydrophilic acrylic intraocular lens and a hydrophobic acrylic device (group E), and a hydrophobic acrylic intraocular lens and a hydrophobic acrylic device (group F). The rabbits were monitored for the ensuing 6 weeks and then killed. The enucleated eyes were evaluated using the Miyake-Apple view, Matlab software analysis, and histology. RESULTS: The posterior capsule opacification score was significantly reduced in the eyes that were implanted with the tested device compared with the control eyes (clinical evaluation: 69% reduction, P = 0.001; the Miyake-Apple view analysis: 77% reduction, P = 0.000; histology: 75% reduction, P = 0.000). Soemmering's ring area was significantly reduced in the eyes implanted with the tested device compared with the control eyes (Matlab analysis: 80% reduction, P = 0.000). CONCLUSIONS: The tested devices were effective in reducing posterior capsule opacification and Soemmering's ring formation. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: To investigate the ability of an open capsule device to prevent posterior capsule opacification. METHODS: A total of 40 eyes of 20 New Zealand white rabbits were randomly divided into six similar groups of 6 to 7 eyes each. After crystalline lens evacuation, one control group (group A) was implanted with a hydrophilic acrylic intraocular lens and no device, and another control group (group B) was implanted with a hydrophobic acrylic intraocular lens and no device. The study groups were implanted with a hydrophilic acrylic intraocular lens and a hydrophilic acrylic device (group C), a hydrophobic acrylic intraocular lens and a hydrophilic acrylic device (group D), a hydrophilic acrylic intraocular lens and a hydrophobic acrylic device (group E), and a hydrophobic acrylic intraocular lens and a hydrophobic acrylic device (group F). The rabbits were monitored for the ensuing 6 weeks and then killed. The enucleated eyes were evaluated using the Miyake-Apple view, Matlab software analysis, and histology. RESULTS: The posterior capsule opacification score was significantly reduced in the eyes that were implanted with the tested device compared with the control eyes (clinical evaluation: 69% reduction, P = 0.001; the Miyake-Apple view analysis: 77% reduction, P = 0.000; histology: 75% reduction, P = 0.000). Soemmering's ring area was significantly reduced in the eyes implanted with the tested device compared with the control eyes (Matlab analysis: 80% reduction, P = 0.000). CONCLUSIONS: The tested devices were effective in reducing posterior capsule opacification and Soemmering's ring formation. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Authors: Jovana Bisevac; Natalia S Anisimova; Richárd Nagymihály; Olav Kristianslund; Kirankumar Katta; Agate Noer; Ilias H Sharafetdinov; Liv Drolsum; Morten C Moe; Boris E Malyugin; Goran Petrovski Journal: Sci Rep Date: 2020-11-25 Impact factor: 4.379