Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Probody therapeutics for targeting antibodies to diseased tissue.

Literature DB >> 24845630

Probody therapeutics for targeting antibodies to diseased tissue.

Abstract

Probodies are proteolytically activated antibodies engineered to remain inert until activated locally in diseased tissue. In principle, any therapeutic antibody can be converted into Probody™ form. In this perspective, we highlight the emerging therapeutic potential of the Probody approach in the form of conventional IgG-based Probodies as well as in the form of 'empowered Probody' formats such as Probody-drug conjugates.

Keywords: EGFR; Jagged; antibody; antibody–drug conjugate; bispecific antibody; chimeric antigen receptor – T cells; probody; protease

Mesh：

Substances：

Year: 2014 PMID： 24845630 DOI： 10.1517/14712598.2014.920814

Source DB: PubMed Journal: Expert Opin Biol Ther ISSN： 1471-2598 Impact factor: 4.388

Keyword Cloud
Cited

17 in total

1. PKCα Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance.

Authors: Kinnari Pandya; Debra Wyatt; Brian Gallagher; Deep Shah; Andrew Baker; Jeffrey Bloodworth; Andrei Zlobin; Antonio Pannuti; Andrew Green; Ian O Ellis; Aleksandra Filipovic; Jason Sagert; Ajay Rana; Kathy S Albain; Lucio Miele; Mitchell F Denning; Clodia Osipo
Journal: Clin Cancer Res Date: 2015-09-08 Impact factor: 12.531

Review 2. Emerging combination immunotherapy strategies for breast cancer: dual immune checkpoint modulation, antibody-drug conjugates and bispecific antibodies.

Authors: Evanthia T Roussos Torres; Leisha A Emens
Journal: Breast Cancer Res Treat Date: 2021-10-30 Impact factor: 4.872

3. Mechanistic insights into the rational design of masked antibodies.

Authors: Carolina T Orozco; Manuela Bersellini; Lorraine M Irving; Wesley W Howard; David Hargreaves; Paul W A Devine; Elise Siouve; Gareth J Browne; Nicholas J Bond; Jonathan J Phillips; Peter Ravn; Sophie E Jackson
Journal: MAbs Date: 2022 Jan-Dec Impact factor: 6.440

4. Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants.

Authors: Jonathan M Labriola; Shane Miersch; Gang Chen; Chao Chen; Alevtina Pavlenco; Reza Saberianfar; Francesca Caccuri; Alberto Zani; Nitin Sharma; Annie Feng; Daisy W Leung; Arnaldo Caruso; Giuseppe Novelli; Gaya K Amarasinghe; Sachdev S Sidhu
Journal: ACS Chem Biol Date: 2022-06-22 Impact factor: 4.634

5. Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches.

Authors: Hwai Wen Chang; Gerhard Frey; Haizhen Liu; Charles Xing; Lawrence Steinman; William J Boyle; Jay M Short
Journal: Proc Natl Acad Sci U S A Date: 2021-03-02 Impact factor: 11.205

Probody therapeutics for targeting antibodies to diseased tissue.

1. PKCα Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance.

Review 2. Emerging combination immunotherapy strategies for breast cancer: dual immune checkpoint modulation, antibody-drug conjugates and bispecific antibodies.

3. Mechanistic insights into the rational design of masked antibodies.

4. Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants.

5. Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches.

Review 6. DNA damaging agent-based antibody-drug conjugates for cancer therapy.

Review 7. Current progress in innovative engineered antibodies.

Review 8. Recent developments in immunotherapy of acute myeloid leukemia.

Review 9. Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation.

10. Activatable Zymography Probes Enable In Situ Localization of Protease Dysregulation in Cancer.