Literature DB >> 2484555

Effect of D-penicillamine on iron uptake by isolated rat hepatocytes.

R Rama1, J Sánchez.   

Abstract

D-penicillamine (beta,beta-dimethylcysteine) promotes the incorporation of iron into isolated rat hepatocytes. The mechanism for doing this remains unknown. No differences in iron distribution between control and treated cells has been observed. Ferritin appears as the main destination of internalized iron in both cases. Therefore, increasing iron storage may appear as a side effect of the use of D-penicillamine as a therapeutic agent for several diseases.

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Year:  1988        PMID： 2484555     DOI： 10.1007/bf02917494

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  18 in total

1.  Effect of dietary D-penicillamine on metabolism of copper in the rat.

Authors:  C A Owen; R V Randall; N P Goldstein
Journal:  Am J Physiol       Date:  1975-01

2.  Penicillamine induced changes in growing rats. II. Liver parenchymal cell.

Authors:  U N Riede; M Roth; J J Molnar; L Bianchi; H P Rohr
Journal:  Experientia       Date:  1971-07

3.  Iron mobilization from cultured rat fibroblasts and hepatocytes. Effect of various drugs.

Authors:  R Rama; J N Octave; Y J Schneider; J C Sibille; J N Limet; J C Mareschal; A Trouet; R R Crichton
Journal:  FEBS Lett       Date:  1981-05-18       Impact factor: 4.124

4.  The interaction of transferrin with isolated hepatocytes.

Authors:  S P Young; P Aisen
Journal:  Biochim Biophys Acta       Date:  1980-12-01

5.  A new assay for cathepsin B1 and other thiol proteinases.

Authors:  A J Barrett
Journal:  Anal Biochem       Date:  1972-05       Impact factor: 3.365

6.  Iron metabolism pathways in the rat hepatocyte.

Authors:  C G Morley; K A Rewers; A Bezkorovainy
Journal:  Clin Physiol Biochem       Date:  1983

7.  Hepatic iron accumulation in copper-deficient rats.

Authors:  D M Williams; F S Kennedy; B G Green
Journal:  Br J Nutr       Date:  1983-11       Impact factor: 3.718

8.  The role of copper in iron metabolism.

Authors:  W Y Chan; O M Rennert
Journal:  Ann Clin Lab Sci       Date:  1980 Jul-Aug       Impact factor: 1.256

9.  Transferrin protein and iron uptake by cultured hepatocytes.

Authors:  J C Sibille; J N Octave; Y J Schneider; A Trouet; R R Crichton
Journal:  FEBS Lett       Date:  1982-12-27       Impact factor: 4.124

10.  Intracellular processing of transferrin and iron by isolated rat hepatocytes.

Authors:  S P Young; S Roberts; A Bomford
Journal:  Biochem J       Date:  1985-12-15       Impact factor: 3.857
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  2 in total

1.  Isolation of the first crystalline D-penicillamine complex of iron and some remarks on relevant aspects of metal-chelating drugs as well as metabolism disorders.

Authors:  A Müller; M Straube; E Krickemeyer; H Bögge
Journal:  Naturwissenschaften       Date:  1992-07

2.  Role of copper accumulation in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats.

Authors:  K Kitaura; Y Chone; N Satake; A Akagi; T Ohnishi; Y Suzuki; K Izumi
Journal:  Jpn J Cancer Res       Date:  1999-04
  2 in total

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